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Search Results - Ion Channels
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  • Membrane Protein Monoclonal Antibodies
    Transmembrane proteins, including multipass membrane proteins (MMP) like G-protein coupled receptors (GPCRs) and ion channels, are essential for cellular function and important ...
    8-1-2013
  • Merck, Bionomics Make Potentially $172M Pact to Search for Chronic...
    The firm describes ionX as a set of technologies for the identification of drugs targeting ion channels for CNS diseases, and MultiCore as a diversity-orientated chemistry platform ...
    7-31-2013
  • Mambalgin Peptide
    Mambalgin-1 has been shown to inhibit the acid-sensing ion channels, ASIC-1a, ASIC-2a, and heteromultimers of these two channel subunits; acid-sensing ion channels play a major ...
    7-1-2013
  • High-Content Screening for Identifying miRNAs Inducing Cardiac...
    These clinically relevant model cells express ion channels and exhibit spontaneous mechanical and electrical activity characteristic of adult cardiomyocytes. With high-content ...
    6-25-2013
  • Stem Cell Science Advances
    ... (CHO) cells-transgenic for a single heart ion channel (HERG), easy to grow, but not even ... cells expressing HERG channels can lead to many false positive and false negative hits." ...
    6-11-2013
  • Lights, Camera, and Lots of Cellular Action
    Phytochrome, phototropin, and light-sensitive ion channels derived from bacteria will be used to create tools for live-cell imaging and optogenetics in the near-term future." ...
    6-1-2013
  • Twin Effort Hones In on Membrane Proteins
    ... Synthelis specializes in making fully functional membrane proteins, including ion channels, porins, and G-protein coupled receptors from humans, animals, bacteria, viruses, and ...
    5-1-2013
  • Steric Exclusion Chromatography
    Examples include ion-exchange chromatography, where solid-phase charges interact ... method are that PEG is virus-stabilizing, and flow-through monolith channels is laminar. ...
    3-15-2013
  • Isolating Membrane Protein Antibodies
    Company Promotes Use of Phage Display with Lipoparticles to Isolate Human Antibodies Integral membrane proteins such as GPCRs, ion channels, and transporters are a large family of ...
    3-15-2013
  • Focusing on Multi-Analyte Detection & Analysis
    ... samples for 15 different indications. "The challenges faced with the technology are membrane proteins such as receptors and ion channels. Those can be tricky proteins to produce. ...
    12-1-2012
  • Deal Struck for Nanobodies Targeting Ion Channels
    and antagonistic functional Nanobodies against both voltage-gated and ligand-gated ion channels. "Due to the formatting flexibility of Nanobodies, we are able to combine ...
    10-2-2012
  • Advertorial: Essen BioScience
    a renowned global Discovery Services team, Essen BioScience provides quantitative assay solutions in an array of research areas including oncology, neuroscience, and ion channels. ...
    10-1-2012
  • Antibody Labeling Turns Stressful
    StressMarq offers a range of purified proteins as western blot controls and activity assays, along with a range of antibodies targeting cellular stress and ion channels and ...
    9-26-2012
  • Merck Pulls Plug on Cardiome Partnership
    Vernakalant IV is not approved for use in the U.S. or Canada. Vernakalant works by selectively blocking multiple ion channels in the heart that are known to be active during ...
    9-26-2012
  • Acquisitions Grow Corning's Product Line
    ... Types of Epic assays include small-molecule binding, functional protease, kinase, protein-protein interactions, G-protein coupled receptors, viral detection, and ion channels. ...
    9-15-2012
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    Journal Articles

  • S-glutathionylation of ion channels: insights into the regulation...
    Yang Yang, Xin Jin, Chun Jiang
    Antioxidants & Redox Signaling
    S-glutathionylation of ion channels: insights into the regulation of channel functions, thiol modification crosstalk and mechanosensing Antioxidants & Redox Signaling
  • The Second Annual Ion Channel Retreat
    Sasko Despotovski, Enal Razvi
    ASSAY and Drug Development Technologies
    The Second Annual Ion Channel Retreat ASSAY and Drug Development Technologies Ion channels are a key therapeutic target class that are relatively unexplored. New technologies and ...
  • Flux Assays in High Throughput Screening of Ion Channels in Drug...
    Sikander Gill, Raj Gill, Soo Sen Lee, J. Christian Hesketh, David Fedida, Saman Rezazadeh, Larisa Stankovich, Dong Liang
    ASSAY and Drug Development Technologies
    Flux Assays in High Throughput Screening of Ion Channels in Drug Discovery ASSAY and Drug Development Technologies Ion channels have been identified as therapeutic targets in ...
  • An Interview with Gregory J. Kaczorowski, Ph.D., Senior Director...

    ASSAY and Drug Development Technologies
    An Interview with Gregory J. Kaczorowski, Ph.D., Senior Director, Department of Ion Channels, Merck Research Laboratories, Rahway, NJ ASSAY and Drug Development Technologies

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