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  • The Tumor Microenvironment as a Drug Target: Chasing Slippery...
    The microenvironment of a cancer is now perceived as an integral part of a tumor's anatomy ... Making use of these targets to fight cancer will require considerable molecular ingenuity. ...
    5-1-2013
  • Isolating Membrane Protein Antibodies
    ... Integral Molecular is combining its Lipoparticle technology with optimized phage protocols to overcome the specific challenges associated with phage display for isolating ...
    3-15-2013
  • Developing Chicken-Derived mAbs
    Crystal Bioscience and Integral Molecular launched a research collaboration to generate panels of chicken monoclonal antibodies against undisclosed therapeutic GPCR and ion channel ...
    11-16-2012
  • Promega Continues Expanding in China
    The building was purchased in June and has since been equipped for the manufacture of molecular biology and molecular diagnostic reagents. "China is an integral part of Promega's ...
    11-15-2012
  • 6 Uses for Biologic Reference Standards
    Reference standards are an integral part of quality determination of and quality control ... acetate-related compound A, and high-molecular weight insulin are specifically used to ...
    10-16-2012
  • SPR Solutions for Interaction Analysis
    ... This interaction is a model system for membrane protein-protein interaction analysis. Lipoparticles were produced by Integral Molecular. (B) Sensorgrams from two channels showing ...
    6-15-2012
  • High-Throughput Alanine Scanning
    ... Integral Molecular has developed a platform technology, Shotgun Mutagenesis, for comprehensive alanine scanning mutagenesis and high-throughput analysis, enabling epitope mapping ...
    6-15-2012
  • Metabolomics Continues Auspicious Climb
    ... of pure molecular compounds. However, in the last two decades, NMR has established itself as a major tool for metabolomics analysis. Since the integral of an NMR signal ...
    5-1-2012
  • Appreciating the Art of Assay Development
    out before, assay development remains an integral-if sometimes behind-the-scenes and ... screens of libraries of molecular inhibitions to generate more reliable hit lists. ...
    4-1-2012
  • Small-Scale Modeling and Predicting
    ... maximal cell density, viability profile, integral of viable cells (IVC), and productivity. ... Peter G. Slade, Ph.D., staff scientist, molecular and cell biology R&D at Life ...
    4-1-2012
  • Harnessing Innovation to Improve Expression Systems
    ... You would have to mutate the membrane-binding domains to make sure the integral membrane ... Blood Coagulation Factors Liang Tang, Ph.D., senior scientist of molecular biology and ...
    3-15-2012
  • RNA Assumes More Prominent Role
    ... Institute investigator and professor of molecular and cell biology and chemistry at the ... secondary structures that become an integral part of cellular gene-expression machinery. ...
    10-15-2011
  • Maximal Humanization of Monoclonal Abs
    Integral Molecular Uses Shotgun Mutagenesis to Germline-Humanize Monoclonal Antibodies Seventy percent of FDA-approved monoclonal antibodies (mAbs) and approximately 66% of mAbs ...
    8-1-2011
  • GABA Therapy Prevents Type 1 Diabetes and Reverses Established...
    ... CD8+ cytotoxic lymphocytes (CTLs), which are integral to the disease process. ... pathway, which may represent a molecular mechanism underlying its in vivo trophic ...
    6-29-2011
  • Epigenomics Secures LifeTech's Dynabeads for Next-Generation...
    MyOne(tm) Silane and buffers as an integral component of latter's second-generation ... of methylation-based molecular diagnostics on its QIAsymphony testing platform. ...
    5-6-2011
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    Journal Articles

  • The Challenges of Incorporating Genetic Testing in the Unified...
    Débora Gusmão Melo, Jorge Sequeiros
    Genetic Testing and Molecular Biomarkers
    Genetic Testing and Molecular Biomarkers Genetic diseases and congenital anomalies are the ... In 2009, the Ministry of Health established the National Policy for Integral Attention in ...
  • S-Glutathionylation: From Molecular Mechanisms to Health Outcomes
    Ying Xiong, Joachim D. Uys, Kenneth D. Tew, Danyelle M. Townsend, D.M. Townsend
    Antioxidants & Redox Signaling
    S-Glutathionylation: From Molecular Mechanisms to Health Outcomes Antioxidants & Redox ... a biological switch and to be integral in a number of critical oxidative signaling events. ...
  • High-Mobility Group Box 1, Oxidative Stress, and Disease
    Daolin Tang, Rui Kang, Herbert J. Zeh, Michael T. Lotze
    Antioxidants & Redox Signaling
    High-mobility group box 1 (HMGB1) protein, a chromatin-binding nuclear protein and damage-associated molecular pattern molecule, is integral to oxidative stress and downstream ...
  • Role of Insulin-Induced Reactive Oxygen Species in the Insulin...
    Barry J. Goldstein, Kalyankar Mahadev, Xiangdong Wu, Li Zhu, Hiroyuki Motoshima
    Antioxidants & Redox Signaling
    with insulin, suggesting that cellular H2O2 generation was integral to insulin signaling. ... By various molecular approaches, Nox4 was shown to mediate insulin-stimulated H2O2 ...

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