Current Issue

View Larger Image

Past Issues Free Subscriptions
Sponsored
Keywords



Search Results - IL-6
 More »

  • RuiYi Licenses mAb Development to China's Genor
    of RYI-008, which is highly selective to IL-6, a cytokine widely implicated in inflammation and cancer. "The clinical data on IL-6 modulation continues to be extremely ...
    5-16-2013
  • RuiYi, CMC Collaborate to Speed mAb Development
    is highly selective to IL-6, a cytokine widely implicated in inflammation and cancer. ... product in the rapidly evolving field of IL-6 biology." said Mark Sawicki, Ph.D., global ...
    5-14-2013
  • Biomarkers Take Center Stage
    ... Markers that exhibited significant differences in plasma concentrations between the two cohorts included CRP, IL-6R alpha, IL-6, IL-1 RA, VEGF, TNF-RII, and IL-17A, IL-17F, and ...
    5-1-2013
  • Addressing Unmet Medical Needs with Complex Carbohydrate Chemistry
    ... shown to be associated with inflammation attributable to increases in tumor necrosis factor alpha (TNF-α), Interleukin-6 (IL-6), and C-reactive proteins, in addition to others. ...
    2-28-2013
  • Shire Rare-Disease Partnerships Expand
    an anti-IL-6 SIMPLE Antibody(tm) discovered and developed by arGEN-X. According to arGEN-X, ARGX-109 has outstanding neutralization potency for the cytokine IL-6, widely ...
    1-7-2013
  • Development of Cytokine Biomarker & Immunogenicity Assays
    ... In addition to IL-8, cytokine assays have recently been validated for IL-1β, IL-6, IL-10, IL-12, IFNγ, and TNFα. Immunogenicity Assays With novel biologic drugs entering the ...
    1-1-2013
  • Advertorial: Quantifying Low-Abundance TH17 Cytokines to Uncover...
    ... Jeff Greenberg, NYU). (A) Markers that exhibited significant differences in plasma concentrations between the two cohorts included CRP, IL-6R alpha, IL-6, IL-1 RA, VEGF, TNF-RII, ...
    12-1-2012
  • WuXi Opens cGMP Biologics Facility in China
    Also last month WuXi and AstraZeneca's biologics subsidiary MedImmune established a joint-venture to develop MEDI5117, an IL-6 inhibitor for rheumatoid arthritis and autoimmune ...
    10-19-2012
  • Marching Toward a "Cyber War" on Cancer
    ... cells' are sent to explore the body (using repulsive signals such as MMP1/collagenase-1 to assist their navigation), and return (using attractive signals such as IL-6 and IL-8). ...
    10-15-2012
  • RuiYi Nabs Rights to arGEN-X IL-6 mAb
    license to ArGEN-X' preclinical anti-IL-6 monoclonal antibody ARGX-109, which is in ... license to ArGEN-X's preclinical anti-IL-6 monoclonal antibody ARGX-109. RuiYi Nabs ...
    10-4-2012
  • A Cyber War on Cancer
    ... cells' are sent to explore the body (using repulsive signals such as MMP1/collagenase-1 to assist their navigation), and return (using attractive signals such as IL-6 and IL-8). ...
    9-19-2012
  • Protein Offers Link Between Smoking and Cardiovascular Disease
    The results confirmed that cessation from smoking rapidly led to reduced levels of both osteoponin and the inflammatory marker IL-6. The researchers say as far as they know their ...
    9-17-2012
  • JV Established to Develop mAb in China
    The fully human IL-6-targeting monoclonal antibody has been developed using MedImmune's YTE half-life extending technology, and is currently in Phase I studies in the U.S. and ...
    9-10-2012
  • A Target for Liver Inflammation and Cancer
    expression of IL-6, IL-1β, TNF, CCL2, and CXCL10, and in addition reduced activation of the p38, extracellular regulated kinase 1/2, JNKL, MAPK, and NF-κB signalling pathways. ...
    8-23-2012
  • Breast Cancer News: Preventing Herceptin Resistance
    to breast cancer therapy that combines an IL-6 inhibitor with Herceptin (Roche's ... on an inflammatory pathway involving IL-6 that propagates tumor cell growth ...
    7-20-2012
  • More »

    Journal Articles

  • Effects of HIV-1 Nef on Virus Co-receptor Expression and Cytokine...
    Maria Giovanna Quaranta, Loredana Falzano, Olimpia Vincentini, Carla Fiorentini, Luciana Giordani, Marina Viora
    Viral Immunology
    In addition, Nef significantly up-regulated IL-6 production by T24 and Caco-2 cells and TNF-a release by all the three cell lines analyzed. Notably, Nef abrogated the IFN-?-induced ...
  • Association between Circulating Tumor Necrosis Factor-Alpha,...
    Ilhan Tarkun, Berrin Çetinarslan, Erdem Türemen, Zeynep Cantürk, Mithat Biyikli
    Metabolic Syndrome and Related Disorders
    factor-alpha (TNF-a) and interleukin-6 (IL-6) concentrations in normal weight women ... globulin (SHBG), 17-hydroxyprogesterone, IL-6, TNF-a concentrations, and insulin ...
  • The Metabolic Syndrome and Inflammation
    Julie P. Sutherland, Benjamin McKinley, Robert H. Eckel
    Metabolic Syndrome and Related Disorders
    Chronic inflammation is frequently associated with the MS. Inflammatory markers that have been associated with MS include hs-CRP, TNF-a, fibrinogen, and IL-6, among others. The ...
  • Cytokine and C-Reactive Protein Profiles Induced by Porcine Circovirus...
    Leanne S. Stevenson, Ken McCullough, Isabelle Vincent, Deirdre F. Gilpin, Artur Summerfield, Jens Nielsen, Francis McNeilly, Brian M. Adair, Gordon M. Allan
    Viral Immunology
    Levels of serum IFN-a, IL-6, IL-10, and CRP were examined for a 35-day period in 10 ... A bioassay was used to detect IL-6 and ELISAs were used to detect IFN-a, IL-10, and CRP. ...

GEN Webinars

View »

GEN Web Briefs

View »

GEN Poll

More » Poll Results » Archive »

Genome Sequencing and Patient Autonomy

Do you think ACMG’s recent recommendations for reporting incidental clinical sequencing results undermine patient autonomy?

Suggest a Poll