Current Issue

View Larger Image

Past Issues Free Subscriptions
Sponsored
Keywords



Search Results - Host-Cell Proteins
 More »

  • Diversifying Your Antibody Portfolio
    ... the development and production of anti-host cell protein lysate (HCP) polyclonal ... detection of low and high molecular proteins and can be incorporated into clearance ...
    5-15-2013
  • Separation of Therapeutic Biomolecules
    (HIC/RPC) for large-scale separation of proteins was the focus of a series of talks at ... confirmed as being effective for host cell protein and double-stranded DNA removal, ...
    5-1-2013
  • Testing for Residual Host Cell Protein & DNA
    Residual host-cell proteins (HCP) and DNA are process impurities that remain in a recombinant drug product following purification. The FDA requires manufacturers to report how much ...
    5-1-2013
  • Boosting Downstream Productivity
    ... Eshmuno CPX removes mAb dimers and higher molecular-weight species, as well as impurities such as host cell proteins (HCP) and leached Protein A, allowing purification of post ...
    4-15-2013
  • Media's Role in Cell Culture Success
    responsible than any other factor in raising production titers for therapeutic proteins. ... processes that allow using the same host cell line and culture medium for whole ...
    4-1-2013
  • Steric Exclusion Chromatography
    ... Early versions of the technique achieved reduction of host cell proteins to the range of 3,000 to 4,000 ppm, but recent improvements support reductions to less than 200 ppm. IgG ...
    3-15-2013
  • HCP Antibodies
    Host-cell protein (HCP) antibodies that detect high, medium, and low-molecular weight proteins are now available. Host-cell proteins are process-related impurities derived from a ...
    3-1-2013
  • Cangene Inks $300+M Deal for Bankrupt Inspiration's IB1001
    The company said the letter is consistent with previous discussions with FDA on the presence of host cell proteins (HCP) in IB1001 that were responsible for formation of anti-HCP ...
    2-20-2013
  • Inner Workings of Immune System Grunts Elucidated
    by the host cell is elicited, which includes the production of an array of defender molecules that work together to block and remove the infection. The IFIT proteins are key ...
    1-14-2013
  • Twisting and Turning for Better Protein Expression
    ... Pfenex produces difficult-to-express proteins by applying "parallel processing" to ... novel gene expression strategies and host cell phenotypes" in less than five weeks. ...
    1-1-2013
  • Close-Up View of Life Science Microscopy
    for example, when a virus infects a host cell, a ligand binds to a membrane receptor, ... size of autofluorescent proteins such as green fluorescent protein and labeled antibodies. ...
    12-1-2012
  • Advertorial: Rapid Quantitation of Monoclonal Antibodies Using...
    ... specificity and are designed to perform titer measurements accurately in the presence of host cell proteins and debris, greatly simplifying analysis at all stages of development. ...
    12-1-2012
  • HBV Target Triggers Viral Replication and Apoptosis
    HBx binding to Bcl-2 family proteins could be an effective therapeutic strategy for treating HBV-related liver disorders without perturbing host cell-signaling pathways," the ...
    10-23-2012
  • Up- and Downstream Go Single Use
    ... which can be used in place of anion exchange chromatography, for flow-through polishing of monoclonal antibody preparations to remove DNA, viruses, and host-cell proteins. ...
    10-1-2012
  • Visterra Inks First Antibody Deal, with Pfizer
    understanding of proteins to aid identifying unique target epitopes and guide drug design. ... early step in the infection cycle that inhibits the entry of the virus into the host cell. ...
    9-11-2012
  • More »

    Journal Articles

  • Evasion of Interferon Responses by Ebola and Marburg Viruses
    Christopher F. Basler, Gaya K. Amarasinghe
    Journal of Interferon & Cytokine Research
    The EBOV VP24 protein inhibits IFN signaling through an interaction with select host cell karyopherin-a proteins, preventing the nuclear import of otherwise activated STAT1. It ...
  • Mouse Monoclonal Immunoglobulin E Antibodies Specific for the...
    Koji Furuya, Shigeru Miwa, Mako Omura, Tokiko Asakura, Kimiaki Yamano, Kosuke Takatori, Shinichi Kudo
    Hybridoma
    polar tube, the extrusion of which is essential for invading a host cell. The polar tube consists of three proteins: polar tube protein 1 (PTP1), PTP2, and PTP3. We established ...
  • The Small Interferon-Induced Transmembrane Genes and Proteins
    Fredy Siegrist, Martin Ebeling, Ulrich Certa
    Journal of Interferon & Cytokine Research
    The Small Interferon-Induced Transmembrane Genes and Proteins Journal of Interferon & ... inflammation could prevent spreading of pathogens by limiting host cell proliferation. ...
  • Reduced Host Cell Invasiveness and Oxidative Stress Tolerance...
    Chantal Loepfe, Eveline Raimann, Roger Stephan, Taurai Tasara
    Foodborne Pathogens and Disease
    Reduced Host Cell Invasiveness and Oxidative Stress Tolerance in Double and Triple csp ... Abstract The cold shock protein (Csp) family comprises small, highly conserved proteins ...

GEN Webinars

View »

GEN Web Briefs

View »

GEN Poll

More » Poll Results » Archive »

Genome Sequencing and Patient Autonomy

Do you think ACMG’s recent recommendations for reporting incidental clinical sequencing results undermine patient autonomy?

Suggest a Poll