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Search Results - HTS
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  • Fluorescence Lifetime Assays
    assay methods prevail in modern HTS. Although invaluable as technologies, the ... As a result of significant improvements in assay reagents and the availability of HTS-comp...
    5-15-2013
  • Predicting Drug Toxicity in Humans
    ... Compagnone's team has developed a cell-based high-throughput screening (HTS) methodology ... It is used in identifying and validating a functional readout in HTS format that can be ...
    4-1-2013
  • 24 Biotech and Biopharma Recruiters
    ... protein chemistry; chromatography; mass spectrometry; high-throughput screening (HTS); microarray; instrumentation; bioinformatics; image analysis equipment; lab supplies ...
    3-18-2013
  • Targeting Protein-Protein Interactions
    ... (HTS)," says Dr. Hansen. "Our investment structure is front loaded, with a relative high up-front investment in libraries and infrastructure (not at all as high as for HTS ...
    2-15-2013
  • Lab Automation Sparks Creativity
    Conventional small molecule discovery is driven by high-throughput screening (HTS) ... Paegel envisions a miniaturized, fully automated HTS instrument that can operate in any ...
    1-1-2013
  • Novel Strategies for Cell-Based Assays
    ... a role more in secondary screening and validation than high-throughput screening (HTS). ... with screening large panels of potential cancer drugs, HTS is definitely the way to go. ...
    1-1-2013
  • Replicating Human Tumor Biology in Vitro
    ... VBI is currently collaborating with a large U.S. biotech company and service provider to explore HTS 3D bioassay applications for oncology and drug toxicity programs. Conclusion ...
    1-1-2013
  • Hundreds of Mutations Potentially Linked to Autism
    sequencing (HTS) played an essential role in discovering numerous new genes that are associated with autism spectrum disorder (ASD). "These new discoveries using HTS confirm that ...
    12-20-2012
  • Tripping The Light Fantastic: New Reporter System
    ... screening (HTS) to identify chemical modulators of cellular pathways (Michelini E et al., Anal Bioanal Chem 2010;398:227-238). However, HTS chemical libraries ...
    12-19-2012
  • Better, Earlier ADME/Tox Predictions in Cells
    ... The significant change is not the models but the methods being applied to measure the endpoints of interest, such as high-content analysis and high-throughput systems (HTS). HTS ...
    12-1-2012
  • Exploiting Flow Cytometry's Full Capabilities
    ... Setting up HTS analyses, we have designed mitochondrial tox assays, including the measurement of membrane potential, cell viability, and glutathione levels. We routinely perform ...
    12-1-2012
  • Multiplexed Drug Assessment in 3D
    HTS-Compatible Assays to Assess Drug Effects in 3D The Infinite M200 PRO is a versatile multimode reader. Most biochemical assays were developed for use on monolayer models and ...
    12-1-2012
  • Advertorial: Quantifying Fluorescent Ligand Binding to GPCRs...
    This results in high content analysis (HCA) assays that are too slow to be useful for high throughput screening (HTS). In this study we use the adjustable focal height feature and ...
    12-1-2012
  • Advertorial: Introduction of a Convenient, Non-Radioactive Universal...
    are desirable for high-throughput screening (HTS) and are the focus of this article. ... and can make the assay impractical for HTS. In addition, these assays suffer from the ...
    12-1-2012
  • Screening by the Millions for the Best Druggable RNA Motifs
    Scientists have developed a solution-based high-throughput screening (HTS) technology that ... combines solution-based HTS with microarray-based selection of the binding RNA motifs. ...
    10-10-2012
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    Journal Articles

  • Resuscitation of Traumatic Brain Injury and Hemorrhagic Shock...
    Hülya Bayir, Vincent A. Vagni, Keri Janesco-Feldman, Lil Ma, Carleton J. Hsia, Robert S.B. Clark, Larry W. Jenkins, C. Edward Dixon, Patrick M. Kochanek, Jennifer L. Exo, David K. Shellington
    Journal of Neurotrauma
    hypertonic (3%) saline (HTS) or lactated Ringer's solution (LR) after TBI plus HS in mice. ... The mice were randomized to resuscitation with LR, HEX, HTS, or PNA, followed by 30?min of ...
  • Improvement of Inhibitor Identification for Heat Shock Protein...
    Jie Qian, Beverly P. Holskin, Jay Theroff, Ted Underiner, Sheryl L. Meyer, Thelma S. Angeles
    ASSAY and Drug Development Technologies
    Thus, identification of HSP90 inhibitors would potentially lead to the discovery of cancer therapeutics. Here, we present a high-throughput screening (HTS) campaign utilizing two ...
  • Retroviral Expression of Escherichia coli Thymidylate Synthase...
    David Shaw, Franklin G. Berger, H. Trent Spencer
    Human Gene Therapy and Part B: Methods
    It was determined that although ecTS is as stable as human TS (hTS) in transfected mammalian cells, ecTS is produced at only 40% the level of hTS, indicating poor translation of ...
  • Nucleofection of Human Embryonic Stem Cells
    Henrike Siemen, Michael Nix, Elmar Endl, Philipp Koch, Joseph Itskovitz-Eldor, Oliver Brüstle
    Stem Cells and Development
    clones. The low quantities of hES cells and DNA required for nucleofection could make this method an attractive tool for miniaturized high throughput screening (HTS) applications.

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