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Search Results - Glycosylation
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  • Analysis of N-Glycan Released from Biopharmaceutical Glycoproteins...
    Unlike conventional drugs, recombinant protein drugs are highly complex molecules with remarkable heterogeneity. Protein glycosylation affects the safety, efficacy, and serum ...
    7-30-2013
  • 10 Minute Charge Heterogeneity Analysis for Development and Quality...
    Charge variants commonly occur as a result of post-translational modification including glycosylation, glycation of lysine residues, amidation, sialylation, and oxidation. These ...
    6-19-2013
  • Advertorial: A Combinatorial, High-Throughput Approach to Protein...
    ... set of operating conditions); highest yield was approximately 10 g/L. MedImmune's pipeline includes novel molecules that do not require glycosylation but are difficult to express. ...
    6-15-2013
  • Getting Creative with Mass Spec
    ... Researchers have successfully used the tool in the analysis of glycosylation, with ... The technique has applications in diagnostics, e.g., a decrease in O-linked glycosylation ...
    6-1-2013
  • Heightened Characterization of Therapeutic mAbs Using a Novel...
    In particular, deep characterization of glycosylation and other post-translational ... modifications (i.e., N-glycosylation, methionine oxidation, etc.) along ...
    5-15-2013
  • Mass Spec Provides Peek into PTMs
    ... Ma concludes. Glycosylation A frozen human prostate tissue slice (10 µm; distal nontumor) ... method has facilitated analysis of glycosylation PTMs associated with different cancers ...
    5-15-2013
  • Glycobiology Analysis Solutions Using HPAE-PAD
    Aberrant glycosylation of proteins is connected to cancer progression, invasion, and metastasis. With many biological functions, glycosylation is one of the most important ...
    4-18-2013
  • Boosting Downstream Productivity
    ... related to the removal of undesirable product variants such as charge variants, glycosylation-, folding-, and truncated mAb-variants. "As biomanufacturing continues to grow ...
    4-15-2013
  • The ABCs of Glycoproteins: How to Combine Analytics, Biology...
    Glycosylation is the most complex post-translational protein modification. More than half ... can have a major impact upon protein glycosylation, which is why this is a critical ...
    3-15-2013
  • Plant-Based Protein Biomanufacturing
    Specific kinds of eukaryotic post-translational modifications-such as glycosylation-must also be considered. Target yield is important in designing a protein expression project. ...
    2-15-2013
  • Cytokines and Growth Factors
    The AF cytokines and growth factors show low proteolytic, pyrogenic, and inflammatory activity. Moreover, they retain eukaryotic folding and glycosylation, which can result in ...
    2-15-2013
  • Resequencing Still Being Targeted
    ... Glycosylation Disorders Congenital disorders of glycosylation (CDG) represents a group of more than 30 autosomal recessive disorders caused by a deficiency in glycosylation. About ...
    1-15-2013
  • Use of Recombinant Human Proteins
    Such authenticity includes structural aspects such as glycosylation, proteolytic processing for mature protein formation, disulfide bond formation, and folding into the proper ...
    1-15-2013
  • Twisting and Turning for Better Protein Expression
    ... Glycosylation Twist Nonhuman glycan structures in available glycoprotein expression systems showing the major differences between human glycosylation and nonhuman glycosylation. ...
    1-1-2013
  • Better Control in Intracellular Flow Assays
    ... an Alexa 647 fluorescent antibody specific for the N-terminal glycosylation of hemoglobin. ... cells have a low staining for glycosylation. (FC 500 flow cytometer, Beckman ...
    1-1-2013
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    Journal Articles

  • N-Linked Glycosylation in C2 Region of HIV-1 Envelope Reduces...
    Sirilak Teeraputon, Suda Louisirirojchanakul, Prasert Auewarakul
    Viral Immunology
    N-Linked Glycosylation in C2 Region of HIV-1 Envelope Reduces Sensitivity to Neutralizing Antibodies Viral Immunology N-linked glycosylation at specific sites on human ...
  • Review and Hypothesis: Does Graves' Disease Develop in Non-Human...
    Sandra M. McLachlan, Kristine Alpi, Basil Rapoport
    Thyroid
    receptor suggested that autoantigen glycosylation was one parameter involved in breaking self-tolerance. Over evolution, TSHR glycosylation increased from three ...
  • HIV Type 1 Mother-to-Child Transmission Facilitated by Distinctive...
    Elly Baan, Anthony de Ronde, Stanley Luchters, Joseph Vyankandondera, Joep M. Lange, Georgios Pollakis, William A. Paxton
    AIDS Research and Human Retroviruses
    HIV Type 1 Mother-to-Child Transmission Facilitated by Distinctive Glycosylation Sites in ... and number of potential N-glycosylation sites (PNGS) in the V1-V2 and the V1-V5 region. ...
  • Optimization of Expression Conditions for Production of Anti...
    Da-Young Park, Jung-Hwan Lee, Yang-Kang So, Young-Kwan Kim, Kinarm Ko, Sang-Won Park, Yong Seok Lee, Yeon Soo Han, Kisung Ko
    Hybridoma
    considered a feasible expression system for recombinant glycoprotein production due to its several advantages, including high capacity, flexibility, and glycosylation capability. ...

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