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Search Results - Glycosylation
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  • Heightened Characterization of Therapeutic mAbs Using a Novel...
    In particular, deep characterization of glycosylation and other post-translational ... modifications (i.e., N-glycosylation, methionine oxidation, etc.) along ...
    5-15-2013
  • Mass Spec Provides Peek into PTMs
    ... Ma concludes. Glycosylation A frozen human prostate tissue slice (10 µm; distal nontumor) ... method has facilitated analysis of glycosylation PTMs associated with different cancers ...
    5-15-2013
  • Glycobiology Analysis Solutions Using HPAE-PAD
    Aberrant glycosylation of proteins is connected to cancer progression, invasion, and metastasis. With many biological functions, glycosylation is one of the most important ...
    4-18-2013
  • Boosting Downstream Productivity
    ... related to the removal of undesirable product variants such as charge variants, glycosylation-, folding-, and truncated mAb-variants. "As biomanufacturing continues to grow ...
    4-15-2013
  • The ABCs of Glycoproteins: How to Combine Analytics, Biology...
    Glycosylation is the most complex post-translational protein modification. More than half ... can have a major impact upon protein glycosylation, which is why this is a critical ...
    3-15-2013
  • Plant-Based Protein Biomanufacturing
    Specific kinds of eukaryotic post-translational modifications-such as glycosylation-must also be considered. Target yield is important in designing a protein expression project. ...
    2-15-2013
  • Cytokines and Growth Factors
    The AF cytokines and growth factors show low proteolytic, pyrogenic, and inflammatory activity. Moreover, they retain eukaryotic folding and glycosylation, which can result in ...
    2-15-2013
  • Resequencing Still Being Targeted
    ... Glycosylation Disorders Congenital disorders of glycosylation (CDG) represents a group of more than 30 autosomal recessive disorders caused by a deficiency in glycosylation. About ...
    1-15-2013
  • Use of Recombinant Human Proteins
    Such authenticity includes structural aspects such as glycosylation, proteolytic processing for mature protein formation, disulfide bond formation, and folding into the proper ...
    1-15-2013
  • Twisting and Turning for Better Protein Expression
    ... Glycosylation Twist Nonhuman glycan structures in available glycoprotein expression systems showing the major differences between human glycosylation and nonhuman glycosylation. ...
    1-1-2013
  • Better Control in Intracellular Flow Assays
    ... an Alexa 647 fluorescent antibody specific for the N-terminal glycosylation of hemoglobin. ... cells have a low staining for glycosylation. (FC 500 flow cytometer, Beckman ...
    1-1-2013
  • Dendritic Cell Generation
    expression system. Unlike nonhuman cell-expressed GM-CSF and IL-4, the HumanKine cytokines possess native human glycosylation and have good stability, half-life, and bioactivity.
    1-1-2013
  • Cevec Inks Another Cell-Line Licensing Agreement
    human-like, including authentic human glycosylation patterns. "We obtained outstanding ... system with its authentic human glycosylation profile will be of great benefit to ...
    12-20-2012
  • Optimizing Cell Lines Improves Production-Really!
    ... By manipulating and optimizing these characteristics and others related to glycosylation, ... In addition to the Bi-Hex subclones varying in glycosylation pattern, Boehringer Ingelheim ...
    11-15-2012
  • Protein Production Prowess Progresses
    ... proteins receive post-translational modifications correctly and efficiently-via glycosylation, for example. "Most biopharmaceuticals on the market or in development are ...
    11-1-2012
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    Journal Articles

  • Amino Acid Mutations in the env gp90 Protein That Modify N-Linked...
    Xiue Han, Jianhua Zou, Xuefeng Wang, Wei Guo, Guicheng Huo, Rongxian Shen, Wenhua Xiang
    Viral Immunology
    Amino Acid Mutations in the env gp90 Protein That Modify N-Linked Glycosylation of the ... in a loss of three potential N-linked glycosylation sites, designated g5, g9, and g10. To ...
  • Enzymatic Glycosylations on Arrays
    Josef Voglmeir, Robert Šardzík, Martin J. Weissenborn, Sabine L. Flitsch
    OMICS: A Journal of Integrative Biology
    OMICS: A Journal of Integrative Biology Abstract The enzymatic glycosylation of ... These arrays and the developed on-chip enzymatic glycosylation methodologies are reviewed ...
  • Mass Spectrometry and Glycomics
    Joseph Zaia
    OMICS: A Journal of Integrative Biology
    Mass Spectrometry and Glycomics OMICS: A Journal of Integrative Biology Abstract Glycosylation defines the adhesive properties of animal cell surfaces and the surrounding ...
  • Pyridoxine Restores Endothelial Cell Function in High Glucose
    Bret G. Kelso, Jeremy B. Brower, Jerome H. Targovnik, Michael R. Caplan
    Metabolic Syndrome and Related Disorders
    Metabolic Syndrome and Related Disorders Abstract Objective: Aminoguanidine, which inhibits the formation of advanced glycosylation end products, can restore the ability of ...

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