Current Issue

View Larger Image

Past Issues Free Subscriptions
Sponsored
Keywords



Search Results - Gleevec
 More »

  • Cancer's Bitter Medicine
    ... The first targeted CML treatment-Novartis' Gleevec (imatinib mesylate), marketed as Glivec ... cost of its drug: "We agree with those who say the price we have set for Gleevec is high. ...
    6-15-2013
  • Acquired Drug Resistance in Cancer
    ... stromal tumors (GIST) in whom disease had progressed despite treatment with imatinib (Gleevec) or sunitinib (Sutent), both multitargeted receptor tyrosine kinase (RTK) inhibitors. ...
    6-1-2013
  • Cancer's Bitter Medicine
    ... The first targeted CML treatment-Novartis' Gleevec (imatinib mesylate), marketed as Glivec ... cost of its drug: "We agree with those who say the price we have set for Gleevec is high. ...
    5-21-2013
  • Companion Diagnostics: 52 Pick-Up
    ... After diagnosis of GIST, results from c-Kit pharmDx may be used as an aid in identifying those patients eligible for treatment with Gleevec/Glivec (imatinib mesylate). InSite Her2/...
    5-9-2013
  • Detecting Acquired Drug Resistance in Cancer
    ... stromal tumors (GIST) in whom disease had progressed despite treatment with imatinib (Gleevec) or sunitinib (Sutent), both multi-targeted receptor tyrosine kinase (RTK) inhibitors. ...
    4-29-2013
  • Fine-Tuning Cell-Based Assays
    ... For example, in cancer research, drug resistance is a major problem. Gleevec, the first kinase inhibitor on the market, was very effective at first for treating blood cancers. But ...
    9-15-2012
  • Oncogene Addiction: Real or Not?
    remains unknown, despite the isolated successes of targeted therapies like imatinib (Gleevec) that targets bcr-abl. "Molecular targeting relies on the assumption that, amidst all ...
    8-17-2012
  • Lasker Awards and Applied Biotechnology
    The 2009 Lasker Awards honor a novel, targeted approach (Gleevec) to cancer therapy and a promising method (nuclear reprogramming) for generating stem cells that avoids the ...
    8-9-2012
  • India's Top Court Set to Hear Novartis Challenge to Patent Law
    At issue is India's 2006 refusal to award Novartis a patent on Gleevec (imatinib), also ... 3(d) the beta-crystalline formulation of Gleevec allowing for greater absorption within ...
    2-29-2012
  • EC Approves Three-Year Treatment Label Update for Novartis' Glivec
    FDA approved a similar label update at the start of February in the U.S. where the drug is called Gleevec. Regulatory clearance in the EU for the three-year treatment ...
    2-27-2012
  • Scientists Say Anticancer Drug Imatinib Can Stop Morphine Tolerance
    Platelet-derived growth factor receptor-β (PDGFR-β) inhibitors such as the anticancer drug imatinib (Gleevec) can prevent or reverse tolerance to morphine analgesia, scientists ...
    2-15-2012
  • FDA Approves Label Change Recommending Three Years of Novartis...
    FDA approved a label amendment to Novartis' oral anticancer therapy Glivec(tm)/Gleevec(tm) ... has demonstrated that longer use of Gleevec can prolong patients' lives in earlier ...
    2-1-2012
  • Protein Kinase Inhibitors for CNS Diseases at the Research and...
    These include small molecule PK inhibitors such as Novartis' Gleevec, Pfizer's Sutent, GlaxoSmithKline's Tykerb, and Bristol-Myers Squibb's Sprycel. PK inhibitors now comprise over ...
    5-27-2011
  • Scientists Visualize Signaling-Triggered Protein Modifications...
    ... the effects on PDGFRβ stimulation of Gleevec, a tyroskine kinase inhibitor that ... As expected, the dual visualization approach correctly showed that Gleevec eliminated the ...
    5-25-2011
  • CytRx Sells Molecular Chaperone Assets to Orphazyme in Deal Worth...
    inhibitor, originally developed by the Nippon Shinyaku, to overcome the limitations of Gleevec and second-line tyrosine kinase inhibitors in resistant chronic myelogenous leukemia. ...
    5-17-2011

  • Journal Articles

  • Ocular Side-Effects Associated with Imatinib Mesylate (Gleevec...
    Frederick W. Fraunfelder, Jonathan Solomon, Brian J. Druker, Bita Esmaeli, Jennifer Kuyl
    Journal of Ocular Pharmacology and Therapeutics
    Ocular Side-Effects Associated with Imatinib Mesylate (Gleevec ® ) Journal of Ocular Pharmacology and Therapeutics This retrospective case series describes ocular side-effects ...
  • Imatinib enhances docetaxel-induced apoptosis through inhibition...
    EunSook Kim, Michiko Matsuse, Vladimir Saenko, Keiji Suzuki, Akira Ohtsuru, Norisato Mitsutake, Shunichi Yamashita
    Thyroid
    Background: We previously reported the partial effectiveness of imatinib (also known as STI571, Glivec, or Gleevec) on anaplastic thyroid cancer (ATC) cells. Imatinib is a ...
  • Involvement of Annexin A1 in Multidrug Resistance of K562/ADR...
    Fengjia Zhu, Yi Wang, Su Zeng, Xiaoyun Fu, Linbo Wang, Jiang Cao
    OMICS: A Journal of Integrative Biology
    Besides the elevated resistance to ADR, the K562/ADR cells also showed significantly increased crossed-resistance to vincristin and Gleevec, compared to the parental K562 cells. ...
  • Enzyme Fragment Complementation Binding Assay for p38 α Mitogen...
    Guido J.R. Zaman, Miranda M.C. van der Lee, Jacobus J. Kok, Rob L.H. Nelissen, Elma E.M.G. Loomans
    ASSAY and Drug Development Technologies
    The fact that some of the most successful kinase inhibitors, such as STI 571 (imatinib mesylate, Gleevec(tm), Novartis Pharmaceuticals, East Hanover, NJ), act through binding to ...

GEN Webinars

View »

GEN Web Briefs

View »

GEN Poll

More » Poll Results » Archive »

Balancing Family and Career for Women Ph.D.s

Which changes made to academic culture are most likely to encourage women researchers to stay?

Suggest a Poll