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  • Childhood Epilepsy Tied to Mutations in Unexpected Genes
    The findings implicated GABRB3 for the first time as a single-gene cause of EE, and offered the strongest evidence to date for the gene's role in any form of epilepsy. Elliott ...
    8-9-2013
  • SCT Licenses Worldwide Rights to Prostate Cancer Stem Cell Assets
    The group has compiled gene expression profiles for various cell types present in prostate tumors and in normal prostate tissue, and have mined data for genes and signaling ...
    8-9-2013
  • Gene by Gene Acquires GE-Backed Arpeggi
    Gene by Gene said today it will acquire Arpeggi, a developer of solutions for genome sequencing, data management, and computational analysis whose backers include General Electric. ...
    8-7-2013
  • What Junk DNA? It's an Operating System
    Noncoding gene sequences control gene expression and influence disease processes. In the August 1 issue of CELL , researchers from the Gene and Stem Cell Therapy Program at ...
    8-6-2013
  • Companion Diagnostics: Improving Development Success and Patient...
    Tafinlar® (dabrafenib), a BRAF inhibitor that targets a certain mutation in the BRAF gene, together with a companion diagnostic identifying patients having that specific mutation. ...
    8-5-2013
  • Using TALENs to Edit Mitochondrial Genes
    (TAL) effectors while looking for new strategies to repair mitochondrial gene defects-more specifically, TAL effector nucleases (TALENs), which can be used for gene editing. ...
    8-5-2013
  • Don't Call It "Junk DNA" Anymore
    Based in the institute's gene and stem cell therapy program, the researchers say they have unraveled a previously unknown mechanism for regulating the activity of genes, thus ...
    8-5-2013
  • Life Tech, RainTree Launch Oncology Testing, Patient Data Initiatives
    ... tools giant going beyond companion diagnostics, into development of a gene therapy that uses infusions of the patients' own T cells genetically engineered to attack their tumors. ...
    8-5-2013
  • Hematologic Diagnostics Go with the Flow
    ... A locus-specific DNA probe for 5q31 (EGR1 gene) was used, along with a control probe specific to the p arm of chromosome 5. FISH was not performed for the confirmation of the 9:19 ...
    8-1-2013
  • New RNA-Based Method for Producing iPSCs
    iPSCs with all the hallmarks of stem cells, including cell surface markers, global gene expression profiles, and in vivo pluripotency, to differentiate into all three germ layers. ...
    8-1-2013
  • Life Tech Licenses Dynabeads to Novartis, with Cancer Therapy...
    tools giant going beyond companion diagnostics-into development of a gene therapy that uses infusions of the patients' own T cells genetically engineered to attack their tumors. ...
    8-1-2013
  • Mouse Arrays for qPCR
    Through a collaboration with Biogazelle, SYBR® Green-based gene expression assays for the mouse genome were designed, optimized, and validated. In addition, the PrimePCR mouse ...
    8-1-2013
  • Microarray Scanner
    The system has been validated for use with comparative genomic hybridization and gene expression microarrays. The SureScan Dx microarray scanner can deliver high sensitivity and ...
    8-1-2013
  • Membrane Protein Monoclonal Antibodies
    ... Ninety-three CXCR4 mAbs were isolated from two hybridoma fusions, 15 ADORA2A mAbs were isolated from a single fusion, and 51 CD20 mAbs from three fusions. Antibody gene sequences ...
    8-1-2013
  • Making Sense of Small Molecules
    profiling technology that would be analogous to a gene-expression chip, for example, where you could do unbiased analysis of small molecules and figure out what's going on." ...
    8-1-2013
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    Journal Articles

  • Assessment of Transcriptional Activity of Borrelia burgdorferi...
    Emir Hodzic, Sunlian Feng, Stephen W. Barthold
    Vector-Borne and Zoonotic Diseases
    Vector-Borne and Zoonotic Diseases Differential gene expression by Borrelia burgdorferi spirochetes during mammalian infection facilitates their dissemination as well as immune ...
  • Increase of Phosphatase and Tensin Homolog by Silymarin to Inhibit...
    Chin-Hui Su, Li-Jen Chen, Jyh Fei Liao, Juei-Tang Cheng
    Journal of Medicinal Food
    Consequently, the level of Bcl-2 expression is decreased (5-6 folds) and caspase 3 is then activated to induce the cell apoptosis. Treatment of siRNA specific to PTEN gene ...
  • Safety and Efficacy of a Genetic Vaccine targeting Telomerase...
    Alessandra Gavazza, George Lubas, Arthur Fridman, Daniela Peruzzi, Joseph A Impellizeri, Laura Luberto, Emanuele Marra, Giuseppe Roscilli, Gennaro Ciliberto, Luigi Aurisicchio
    Human Gene Therapy and Part B: Methods
    Safety and Efficacy of a Genetic Vaccine targeting Telomerase plus Chemotherapy for the therapy of canine B-cell lymphoma Human Gene Therapy and Part B: Methods Client-owned pet ...
  • Effects of OPRM1 A118G Polymorphism on Epidural Analgesia with...
    Zheming Song, Boxiang Du, Kai Wang, Xueyin Shi
    Genetic Testing and Molecular Biomarkers
    Background: Emerging evidence has shown that the most common polymorphism (A118G; rs1799971 A>G) in the OPRM1 gene may influence the response to labor analgesia; but individually ...

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