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Search Results - Gene Silencing
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  • Even at "Safe" Levels, Potentially Mutagenic Agents in Combination...
    Justin Treas, Ph.D., a postdoc in Dr. Singh's lab pinpointed the gene MLH1 as one target ... by hypermethylation-mediated silencing of MLH1" was published online in The ...
    7-1-2013
  • Metagenomics May Hold Key to Novel Antibiotic Discovery
    ... encoded in the genomes of uncultured bacteria, but that gene silencing can hamper the functional characterization of gene clusters captured on such environmental DNA clones. ...
    6-4-2013
  • Cenix, Debiopharm Launch Biomarker Collaboration
    on preclinical cell-based and in vivo applications including RNAi-based gene silencing, miRNA modulation, compound testing, advanced genomics analyses and high content screening. ...
    5-23-2013
  • Twin Study Elucidates Epigenetics' Role in Autism
    The team studied DNA methylation, which acts to block the genetic sequences that drive gene expression, silencing gene activity. They examined DNA methylation at over 27,000 sites ...
    4-23-2013
  • Epigenetics Opens New Avenues for DNA Research
    ... to cause epigenetic changes that include aberrant DNA methylation and post-translational histone modifications, causing changes in chromosomal condensation and gene silencing. ...
    4-1-2013
  • Flipping the Genetic Switch
    ... more highly methylated CpG islands (genomic areas with large numbers of cytosine-guanine pairs), which are often associated with gene transcriptional silencing of promoters. ...
    3-28-2013
  • DNA Methylation Rules: Studying Epigenetics with New Tools
    In particular, de novo methylation of tumor suppressor gene promoters occurs frequently in cancers, thereby silencing them and promoting transformation. Cytosine hydroxymethylation ...
    2-6-2013
  • Costly Cats: Dispelling Allergies-to-Animals Mythology
    ... Using a gene-silencing strategy, the investigators specifically inhibited the expression of MR on human monocyte-derived DCs. They showed that silencing MR expression on ...
    12-12-2012
  • Overcoming Drawbacks of Gene Silencing with RNAi
    Tools for Effective Validation and Utilization Gene silencing by RNA interference has become a key tool in research and drug discovery since its discovery by Andrew Fire and Craig ...
    12-1-2012
  • Understanding Genetic Risk for Diabetes
    the scientists can manipulate gene activity in the most widely used mouse ... The paper is titled "PTPN22 Silencing in the NOD Model Indicates the Type 1 ...
    11-29-2012
  • RNAi's Enabling Powers
    ... or established cell lines, adherent or in suspension, all cells tested readily take up the sd-rxRNA based on their structure and show significant gene silencing, greater than 70%." ...
    11-1-2012
  • Epigenetics Study Identifies Gastric Cancer Subtype
    Over 97% of these gene-silencing methylated CpG sites were within gene promotor regions. The studies also identified long-range regions of epigenetic silencing (LRESs) within the ...
    10-18-2012
  • Gene Expression Analysis Reshapes Biomedical Research
    ... Jones and colleagues used gene expression meta-analysis to define the regions that are dependent on DNA methylation-dependent gene silencing. Their strategy helped identify a set ...
    10-1-2012
  • The Empty (and Misleading) Promises of Do-It-Yourself Genetic...
    ... that DNA sequence is only the first stage of gene expression. One must consider such events as RNA splicing, RNA silencing, and protein modifications (to name a few) if one ...
    9-6-2012
  • Honing In On Gene Delivery Targets
    ... things, that they need not worry about the random integration of vector (and all that entails in terms of transgene or endogenous gene silencing or endogenous gene activation). ...
    9-1-2012
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    Journal Articles

  • HISTONE DEACETYLASE INHIBITION AFFECTS SODIUM IODIDE SYMPORTER...
    Mariateresa Pugliese, Nicoletta Fortunati, Antonina Germano, Sofia Asioli, Francesca Marano, Nicola Palestini, Roberto Frairia, Giuseppe Boccuzzi, Maria Graziella Catalano
    Thyroid
    mainly due to epigenetic silencing. The acetylation status of histones is involved in the epigenetic control of gene expression and is usually disrupted in advanced thyroid cancer. ...
  • Directing Neuronal Differentiation of Primary Neural Progenitor...
    Wei Ching Low, Winifred Wing Yiu Yau, Lawrence W. Stanton, Guillaume Marcy, Eyleen Goh, Sing Yian Chew
    DNA and Cell Biology
    Directing Neuronal Differentiation of Primary Neural Progenitor Cells by Gene Knockdown ... In this study, in vitro silencing of RE1-silencing transcription factor (REST) was carried ...
  • Identification and Allele-Specific Silencing of the Mutant Huntingtin...
    P.H.J. van Bilsen, L. Jaspers, M.S. Lombardi, J.C.E. Odekerken, E.N. Burright, W.F. Kaemmerer
    Human Gene Therapy and Part B: Methods
    Identification and Allele-Specific Silencing of the Mutant Huntingtin Allele in Huntington's Disease Patient-Derived Fibroblasts Human Gene Therapy and Part B: Methods
  • Regulation Exerted by miRNAs in the Promoter and UTR Sequences...
    Julia D. Toscano-Garibay, Guillermo Aquino-Jarquin
    DNA and Cell Biology
    DNA/RNA) stabilized by Argonaute 2. Also, we classified transcriptional gene silencing (1) by homology, represented by small interfering RNAs directed to viral ...

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