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Search Results - Gene Editing
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  • Using TALENs to Edit Mitochondrial Genes
    (TAL) effectors while looking for new strategies to repair mitochondrial gene defects-more specifically, TAL effector nucleases (TALENs), which can be used for gene editing. ...
    8-5-2013
  • CRISPR/Cas Comes of Age-Almost
    ... CRISPR array to enable simultaneous editing of several sites within the mammalian ... and antimicrobial resistance genes between bacteria through horizontal gene transfer. ...
    7-24-2013
  • Six Websites You Need to Bookmark: August Picks
    ... that are available for image viewing and editing; however, the "best practices" guidelines ... what they say: Gene regulators come in small packages (or, you know, something like that). ...
    7-22-2013
  • Genomic Data Analyses Implicate Immune Proteins in Mutagenesis...
    A group of proteins involved in innate immunity known as apolipoprotein B mRNA-editing ... To accomplish this, Minnesota's Reuben Harris, Ph.D., and his colleagues analyzed gene ...
    7-15-2013
  • Gene Editing Gone Awry: CRISPR RGNs Can Cause Unwanted Mutations
    CRISPR RNA-guided nucleases (RGNs) have drummed up much excitement among scientists in the gene- and genome-editing fields. And for good reason: Studies have shown ...
    6-24-2013
  • Gene Editing to Treat Genetic Diseases, Part II
    Women can be carriers of the disorder but rarely exhibit symptoms of the disease. Last week, Part I of this two-part series of articles focused on gene editing strategies involving ...
    6-20-2013
  • New CHO Cell Lines on the Horizon for Hisun
    inhibitor of GS. Horizon, which engineered the CHO cell line using its GENESIS(tm) gene editing technology, claims that the precision afforded by GENESIS results in an optimal ...
    6-18-2013
  • Genome 2.0: First Form, Now Function
    ... using ectopic overexpression vectors, which in no way recapitulate normal gene function. ... But what are the techniques available now and what can they do? Genome editing techniques ...
    6-15-2013
  • Gene Editing with Multiple Molecular Means
    Conceptually, manipulating a gene product at either the DNA level through editing to restore production of a functional protein, or at the translational level by preventing ...
    6-12-2013
  • Highlights from AACR
    Several posters displayed by Horizon Discovery highlighted the capabilities of its Genesis(tm) precision gene-editing technology. In one, Grooby et al., described an siRNA screen ...
    5-15-2013
  • "GEN 10" Award Winners Announced
    development of a novel genome editing technology Kirthi Kumar Kutumbaka, Northern Illinois University, Abstract: Identification of a new gene required for coenzyme Q ...
    4-22-2013
  • Cocoons of Monster Silk Spun in Pilot Production Program
    negotiated a license to use Sigma Life Science's CompoZr zinc-finger nuclease (ZFN) gene-editing technology for generating genetically modified silkworms that produce spider silk. ...
    3-4-2013
  • New Centers of Excellence on the Horizon in Asia
    Horizon Discovery has established three new Centers of Excellence (CoEs) for gene editing in Asia. The new centers are at Aichi Cancer Center, Japan, Seoul National University, ...
    3-4-2013
  • Genome Editing for R&D and Therapeutics
    Many feel that gene editing promises to write the next chapter in biomedicine. Science described new gene editing technologies as "genomic cruise missiles" and named them as ...
    3-1-2013
  • Footprint-Free, Site-Specific Gene Editing
    ... Thus, an ideal gene-editing system must include some mechanism by which this marker can be excised cleanly from the genome once the desired mutant cells have been selected. Until ...
    3-1-2013
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    Journal Articles

  • Hepatic Expression of the Catalytic Subunit of the Apolipoprotein...
    Karen F. Kozarsky, Denise K. Bonen, Federico Giannoni, Toru Funahashi, James M. Wilson, Nicholas O. Davidson
    Human Gene Therapy and Part B: Methods
    Hepatic Expression of the Catalytic Subunit of the Apolipoprotein B mRNA Editing Enzyme ( apobec -1) Ameliorates Hypercholesterolemia in LDL Receptor-Deficient Rabbits Human Gene ...
  • Gene Transfer of Cytidine Deaminase apoBEC-1 Lowers Lipoprotein...
    Steven D. Hughes, Didier Rouy, Naveenan Navaratnam, James Scott, Edward M. Rubin
    Human Gene Therapy and Part B: Methods
    Gene Transfer of Cytidine Deaminase apoBEC-1 Lowers Lipoprotein(a) in Transgenic Mice and Induces Apolipoprotein B Editing in Rabbits Human Gene Therapy and Part B: Methods
  • Tipping the Balance: Antagonism of PKR Kinase and ADAR1 Deaminase...
    Cyril X. George, Zhiqun Li, Kristina M. Okonski, Ann M. Toth, Ying Wang, Charles E. Samuel
    Journal of Interferon & Cytokine Research
    Tipping the Balance: Antagonism of PKR Kinase and ADAR1 Deaminase Functions by Virus Gene ... Because I is recognized as G instead of A, A-to-I editing by ADAR1 can lead to genetic ...
  • Genetic Therapeutic Approaches for Duchenne Muscular Dystrophy
    Helen Foster, Linda Popplewell, George Dickson
    Human Gene Therapy and Part B: Methods
    by antisense oligonucleotide-induced exon skipping to restore the open reading frame; and direct modification of the DMD gene at a chromosomal level through genome editing. ...

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