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Search Results - Gene Editing
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  • HIV Researchers Seek a Potential Cure
    ... explains, "One is an activator of the editing enzyme known as APOBEC3G (A3G) that can ... alter the current thinking about HIV and gene therapy," Kevin Robert Frost, CEO, amfAR, ...
    10-1-2013
  • Gene Editing Typos
    Researchers use a human cell-based reporter assay to characterize off-target cleavage of CRISPR-associated (Cas)9-based RNA-guided nucleases. Gene editing is a method to introduce ...
    10-1-2013
  • Human Disease Models Move Underwater
    ... Moreover, recently developed technologies for gene editing-zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), CRISP/CAS-9-are rapidly moving ...
    10-1-2013
  • CRISPR/Cas Comes of Age-Almost
    ... CRISPR array to enable simultaneous editing of several sites within the mammalian ... and antimicrobial resistance genes between bacteria through horizontal gene transfer. ...
    9-1-2013
  • Gene Editing Innovation: User-Friendly TALEs
    ... Investigators at The Scripps Research Institute (TSRI) say they have found a way to use a new DNA-editing technology more broadly than in the past Gene Editing Innovation: ...
    8-27-2013
  • Using TALENs to Edit Mitochondrial Genes
    (TAL) effectors while looking for new strategies to repair mitochondrial gene defects-more specifically, TAL effector nucleases (TALENs), which can be used for gene editing. ...
    8-5-2013
  • CRISPR/Cas Comes of Age-Almost
    ... CRISPR array to enable simultaneous editing of several sites within the mammalian ... and antimicrobial resistance genes between bacteria through horizontal gene transfer. ...
    7-24-2013
  • Six Websites You Need to Bookmark: August Picks
    ... that are available for image viewing and editing; however, the "best practices" guidelines ... what they say: Gene regulators come in small packages (or, you know, something like that). ...
    7-22-2013
  • Genomic Data Analyses Implicate Immune Proteins in Mutagenesis...
    A group of proteins involved in innate immunity known as apolipoprotein B mRNA-editing ... To accomplish this, Minnesota's Reuben Harris, Ph.D., and his colleagues analyzed gene ...
    7-15-2013
  • Gene Editing Gone Awry: CRISPR RGNs Can Cause Unwanted Mutations
    CRISPR RNA-guided nucleases (RGNs) have drummed up much excitement among scientists in the gene- and genome-editing fields. And for good reason: Studies have shown ...
    6-24-2013
  • Gene Editing to Treat Genetic Diseases, Part II
    Women can be carriers of the disorder but rarely exhibit symptoms of the disease. Last week, Part I of this two-part series of articles focused on gene editing strategies involving ...
    6-20-2013
  • New CHO Cell Lines on the Horizon for Hisun
    inhibitor of GS. Horizon, which engineered the CHO cell line using its GENESIS(tm) gene editing technology, claims that the precision afforded by GENESIS results in an optimal ...
    6-18-2013
  • Genome 2.0: First Form, Now Function
    ... using ectopic overexpression vectors, which in no way recapitulate normal gene function. ... But what are the techniques available now and what can they do? Genome editing techniques ...
    6-15-2013
  • Gene Editing with Multiple Molecular Means
    Conceptually, manipulating a gene product at either the DNA level through editing to restore production of a functional protein, or at the translational level by preventing ...
    6-12-2013
  • Highlights from AACR
    Several posters displayed by Horizon Discovery highlighted the capabilities of its Genesis(tm) precision gene-editing technology. In one, Grooby et al., described an siRNA screen ...
    5-15-2013
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    Journal Articles

  • Gene Transfer of Cytidine Deaminase apoBEC-1 Lowers Lipoprotein...
    Steven D. Hughes, Didier Rouy, Naveenan Navaratnam, James Scott, Edward M. Rubin
    Human Gene Therapy and Part B: Methods
    Gene Transfer of Cytidine Deaminase apoBEC-1 Lowers Lipoprotein(a) in Transgenic Mice and Induces Apolipoprotein B Editing in Rabbits Human Gene Therapy and Part B: Methods
  • Synthetic Zinc Finger Nuclease Design and Rapid Assembly
    Mark J. Osborn, Anthony P. DeFeo, Bruce R. Blazar, Jakub Tolar
    Human Gene Therapy and Part B: Methods
    This oligonucleotide-based isothermal DNA assembly protocol was used to determine whether we could generate functional nucleases capable of endogenous gene editing. We targeted the ...
  • Versatile and Efficient Genome Editing in Human Cells by Combining...
    Eva-Maria Händel, Katharina Gellhaus, Kafaitullah Khan, Christien Bednarski, Tatjana I. Cornu, Felix Müller-Lerch, Robert M. Kotin, Regine Heilbronn, Toni Cathomen
    Human Gene Therapy and Part B: Methods
    Versatile and Efficient Genome Editing in Human Cells by Combining Zinc-Finger Nucleases With Adeno-Associated Viral Vectors Human Gene Therapy and Part B: Methods Abstract ...
  • Chimeric RNA/Ethylene-Bridged Nucleic Acids Promote Dystrophin...
    Agus Surono, Tran Van Khanh, Yasuhiro Takeshima, Hiroko Wada, Mariko Yagi, Miho Takagi, Makoto Koizumi, Masafumi Matsuo
    Human Gene Therapy and Part B: Methods
    by Inducing Skipping of the Nonsense Mutation-Encoding Exon Human Gene Therapy and Part B: Methods Editing of dystrophin mRNA by induction of exon skipping, using antisense ...

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