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Search Results - Gene Editing
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  • Highlights from AACR
    Several posters displayed by Horizon Discovery highlighted the capabilities of its Genesis(tm) precision gene-editing technology. In one, Grooby et al., described an siRNA screen ...
    5-15-2013
  • "GEN 10" Award Winners Announced
    development of a novel genome editing technology Kirthi Kumar Kutumbaka, Northern Illinois University, Abstract: Identification of a new gene required for coenzyme Q ...
    4-22-2013
  • Cocoons of Monster Silk Spun in Pilot Production Program
    negotiated a license to use Sigma Life Science's CompoZr zinc-finger nuclease (ZFN) gene-editing technology for generating genetically modified silkworms that produce spider silk. ...
    3-4-2013
  • New Centers of Excellence on the Horizon in Asia
    Horizon Discovery has established three new Centers of Excellence (CoEs) for gene editing in Asia. The new centers are at Aichi Cancer Center, Japan, Seoul National University, ...
    3-4-2013
  • Genome Editing for R&D and Therapeutics
    Many feel that gene editing promises to write the next chapter in biomedicine. Science described new gene editing technologies as "genomic cruise missiles" and named them as ...
    3-1-2013
  • Footprint-Free, Site-Specific Gene Editing
    ... Thus, an ideal gene-editing system must include some mechanism by which this marker can be excised cleanly from the genome once the desired mutant cells have been selected. Until ...
    3-1-2013
  • Sigma and Olink Partner on Protein-Protein Interaction Assay
    The technology, among other applications, can be used in combination with CompoZr® Zinc Finger Nuclease-mediated gene editing to track knocked-out or knocked-in genes and with ...
    2-12-2013
  • Tying Up Loose Ends in Cell-Line Development
    ... nuclease-assisted genome editing for cell-line development. Applications include basic research for functional studies using reporters with gene tagging, promoter and enhancer ...
    2-1-2013
  • Reporter Kits
    The kits include genetically defined reporter cell lines generated using Genesis(tm) gene editing technology with Promega's luminescent and fluorescent reporter technologies.
    2-1-2013
  • Horizon Deal Supports Boehringer Ingelheim Drug Discovery
    In November 2012, the company inked a gene-editing research collaboration with the Institute of Neurology, University College London, providing access to GENESIS. Horizon Deal ...
    1-14-2013
  • New Method Enables Multiplex Genome Engineering
    ... studied the editing system in mouse and human cells, the system could be used to design new therapies for diseases such as Huntington's disease, caused by a single abnormal gene. ...
    1-3-2013
  • GEN Ten Survey Results
    Gene Editing permits a more detailed study of gene function and opens up the doors to novel approaches to gene therapy through the use of transcription activator-like effector ...
    1-1-2013
  • Improving Molecular Genetic Testing
    ... Using precise gene-editing technology, Horizon Diagnostics has created a new generation of molecular reference standards based on having a tightly defined allele burden and common ...
    12-1-2012
  • Methylated Gene Targeting
    Users can target any gene at any position in any cell type regardless of methylation status. The service can make gene editing accessible for therapeutic applications, cancer ...
    12-1-2012
  • Boosting Gene Expression Profiling
    ... Instead of concentrating on exons and mRNA for analysis, Dr. Bowcock screened miRNAs for changes in gene expression, including modifications in miRNA editing. The advantage of ...
    11-15-2012
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    Journal Articles

  • Tipping the Balance: Antagonism of PKR Kinase and ADAR1 Deaminase...
    Cyril X. George, Zhiqun Li, Kristina M. Okonski, Ann M. Toth, Ying Wang, Charles E. Samuel
    Journal of Interferon & Cytokine Research
    Tipping the Balance: Antagonism of PKR Kinase and ADAR1 Deaminase Functions by Virus Gene ... Because I is recognized as G instead of A, A-to-I editing by ADAR1 can lead to genetic ...
  • Genetic Therapeutic Approaches for Duchenne Muscular Dystrophy
    Helen Foster, Linda Popplewell, George Dickson
    Human Gene Therapy and Part B: Methods
    by antisense oligonucleotide-induced exon skipping to restore the open reading frame; and direct modification of the DMD gene at a chromosomal level through genome editing. ...
  • Synthetic Zinc Finger Nuclease Design and Rapid Assembly
    Mark J. Osborn, Anthony P. DeFeo, Bruce R. Blazar, Jakub Tolar
    Human Gene Therapy and Part B: Methods
    This oligonucleotide-based isothermal DNA assembly protocol was used to determine whether we could generate functional nucleases capable of endogenous gene editing. We targeted the ...
  • Expanding the Spectrum of Genetic Elements Transferable by Retroviral...
    Magnus Blø, Jakob M. Bogenberger, Susan E. Swift, David R. Micklem, James B. Lorens
    DNA and Cell Biology
    This limits the scope of genetic elements that may be transferred by these vectors, excluding many key gene regulatory signals, including RNA editing motifs, alternative splicing, ...

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