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Search Results - Gene Delivery
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  • New RNA-Based Method for Producing iPSCs
    random integration of retroviral-based delivery vectors into the genome, and unregulated ... including cell surface markers, global gene expression profiles, and in vivo ...
    8-1-2013
  • Membrane Protein Monoclonal Antibodies
    ... 51 CD20 mAbs from three fusions. Antibody gene sequences from SDIX mAbs revealed highly ... The intrinsically gentle antigen delivery process of DNA immunization may explain this ...
    8-1-2013
  • Big Need in IBD: Drugs to Slow Progression
    important improvements such as enhanced delivery or administration," she explains. "There ... A recent finding at the University of Cambridge resulted in a gene expression profile to ...
    8-1-2013
  • ReGenX, Audentes Team Up to Develop Rare Muscle Disease Treatments
    technology is based on NAV vectors, which the firm describes as the next generation of recombinant adeno-associated virus (rAAV) vectors used for in vivo therapeutic gene delivery. ...
    7-30-2013
  • 10 Industry-Venture Fund Alliances
    ... drug delivery technologies, diagnostics, biotechnology, and medical devices. ... as well as in emerging technologies that include gene therapy and synthetic biology. ...
    6-20-2013
  • Gene Editing to Treat Genetic Diseases, Part II
    ... Gersbach says his group is now conducting further tests of this new approach in animal models of the disease, as well as exploring delivery of the gene correcting enzymes directly ...
    6-20-2013
  • Top 20 Corporate Venture Funds
    ... and animal health; diagnostics or drug delivery systems. "We look for unmet need and ... pharmaceuticals, regenerative medicine, gene therapies, and tissue and organ engineering. ...
    6-14-2013
  • Making Vaccines from Parts
    less-than timely vaccine manufacture and delivery responses during past influenza ... segments, the accuracy of rapid gene synthesis, and the yield of HA from vaccine viruses. ...
    5-14-2013
  • Novartis, Oxford BioMedica Ink Production Agreement for Lentiviral...
    Oxford BioMedica has agreed to produce clinical trial material using its LentiVector® gene delivery technology for Novartis' use as part of its CTL019 leukemia program, a ...
    5-1-2013
  • Comparative Genomics: Insights into Disease Susceptibility
    ... Using targeted delivery of RNA interference, to either disrupt (rats) or abolish (monkeys) ... that menstrual cycles went haywire when hypothalamic EAP1 gene expression was blocked. ...
    5-1-2013
  • Advances in RNAi Tools and Technologies
    ... effect, claims Dr. Rozema. He says delivery with one monthly injection is enough to induce 90% knockdown of the target gene in mice; in nonhuman primates, over 80% ...
    4-15-2013
  • Is This Gene Therapy's Breakout Moment?
    ... That has to do with delivery-do we know what the gene should be? For a recessive genetic disease, that's clear. If it's an acquired disease, where you're going to remodel a tissue, ...
    4-1-2013
  • Ziopharm Restructuring After Phase III Failure
    Ziopharm's DNA synthetic biology platform employs an inducible gene delivery system designed to enable controlled delivery of genes that produce therapeutic proteins to treat ...
    3-26-2013
  • Molecular Roots of Down Syndrome Unraveled
    ... The team explored this possibility. They used a noninfectious virus as a delivery vehicle ... Xu's lab and first author of the study. "Gene therapy of this sort hasn't really panned ...
    3-25-2013
  • Gene Discovery Portends Schizophrenia Paradigm Shift
    ... specific treatments and clinical service delivery and pursue more personalized treatment ... schizophrenia may be explained by a single gene that regulates a group of other ...
    3-5-2013
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    Journal Articles

  • BMP-2 plasmid DNA as a substitute for BMP-2 protein in bone tissue...
    Fiona Wegman, Yvonne van der Helm, F Cumhur Oner, Wouter Dhert, Jacqueline Alblas
    Tissue Engineering, Part A
    We compared the effectivity of transient BMP-2 gene delivery with BMP-2 protein at clinical (high) and physiological (low) doses by subcutaneous implantation of alginate-based ...
  • Dual delivery of rhPDGF-BB and bone marrow mesenchymal stromal...
    Shin-Young Park, Kyoung-Hwa Kim, Seung-Yun Shin, Ki-Tae Koo, Yong-Moo Lee, Yang Jo Seol
    Tissue Engineering, Part A
    Dual delivery of rhPDGF-BB and bone marrow mesenchymal stromal cells expressing the BMP2 gene enhance bone formation in a critical-sized defect model Tissue Engineering, Part A ...
  • The Effect of Aerosol Polyethylenimine/Interferon-γ Plasmid...
    Zhuang Ma, Wenwu Sun
    Journal of Aerosol Medicine and Pulmonary Drug Delivery
    in immune function of the lung. In this study, we tested whether aerosol delivery the gene of interferon gamma (IFN?) could affect inflammatory cytokine expression in mouse lung. ...
  • Coarse Spray Delivery to a Localized Region of the Pulmonary...
    D. C. Cipolla, I. Gonda, S. Shak, I. Kovesdi, R. Crystal, T. D. Sweeney
    Human Gene Therapy and Part B: Methods
    Coarse Spray Delivery to a Localized Region of the Pulmonary Airways for Gene Therapy Human Gene Therapy and Part B: Methods

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