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Search Results - Gene Delivery
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  • Making Vaccines from Parts
    less-than timely vaccine manufacture and delivery responses during past influenza ... segments, the accuracy of rapid gene synthesis, and the yield of HA from vaccine viruses. ...
    5-14-2013
  • Novartis, Oxford BioMedica Ink Production Agreement for Lentiviral...
    Oxford BioMedica has agreed to produce clinical trial material using its LentiVector® gene delivery technology for Novartis' use as part of its CTL019 leukemia program, a ...
    5-1-2013
  • Comparative Genomics: Insights into Disease Susceptibility
    ... Using targeted delivery of RNA interference, to either disrupt (rats) or abolish (monkeys) ... that menstrual cycles went haywire when hypothalamic EAP1 gene expression was blocked. ...
    5-1-2013
  • Advances in RNAi Tools and Technologies
    ... effect, claims Dr. Rozema. He says delivery with one monthly injection is enough to induce 90% knockdown of the target gene in mice; in nonhuman primates, over 80% ...
    4-15-2013
  • Is This Gene Therapy's Breakout Moment?
    ... That has to do with delivery-do we know what the gene should be? For a recessive genetic disease, that's clear. If it's an acquired disease, where you're going to remodel a tissue, ...
    4-1-2013
  • Ziopharm Restructuring After Phase III Failure
    Ziopharm's DNA synthetic biology platform employs an inducible gene delivery system designed to enable controlled delivery of genes that produce therapeutic proteins to treat ...
    3-26-2013
  • Molecular Roots of Down Syndrome Unraveled
    ... The team explored this possibility. They used a noninfectious virus as a delivery vehicle ... Xu's lab and first author of the study. "Gene therapy of this sort hasn't really panned ...
    3-25-2013
  • Gene Discovery Portends Schizophrenia Paradigm Shift
    ... specific treatments and clinical service delivery and pursue more personalized treatment ... schizophrenia may be explained by a single gene that regulates a group of other ...
    3-5-2013
  • Is This Gene Therapy's Breakout Moment?
    ... That has to do with delivery-do we know what the gene should be? For a recessive genetic disease, that's clear. If it's an acquired disease, where you're going to remodel a tissue, ...
    3-4-2013
  • Genome Editing for R&D and Therapeutics
    ... Gregory. "We designed a ZFN approach in mice that could induce gene targeting in the liver to allow delivery and correction of the mutated gene. This strategy succeeded in the ...
    3-1-2013
  • Exploiting miRNA's Potential for Diagnostics and Drugs
    ... Viral-Mediated miRNA Therapeutics Cellular delivery of miRNAs via cytoplasmic-based ... and use it to generate siRNAs to silence a desired host gene," Dr. tenOever reported. ...
    2-15-2013
  • Unlocking Biomarkers' Full Potential
    to address the needs of the multiple delivery systems in the world-from the ... The division is developing the Pervenio(tm) Lung RS assay, a 14-gene expression profile ...
    2-1-2013
  • SBIR Thinks Smaller
    ... development, manufacturing, and delivery of therapeutics. "With the new rules ... of bovine immunodeficiency virus (BIV) gene therapy vectors into mammalian cells. ...
    1-22-2013
  • 5 Reasons to Use OCT in Preclinical Studies
    ocular dose: Many gene- and cell-based therapies require a localized dose near the site of therapeutic interest. In the eye, this often involves a depot delivery such as ...
    1-21-2013
  • Technologies Evolving for Cellular Therapies
    The solutions offered by Fisher BioServices vary, and may involve just-in-time delivery, ... tools, such as qPCR/digital PCR platforms, gene and RNA sequencing platforms, flow ...
    1-15-2013
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    Journal Articles

  • Comparison of Viral and Nonviral Vectors for Gene Transfer to...
    Brian Kealy, Aaron Liew, Jill M. McMahon, Thomas Ritter, Aideen O'Doherty, Melissa Hoare, Udo Greiser, Erin E. Vaughan, Martin Maenz, Ciara O'Shea, Frank Barry, Timothy O'Brien
    Tissue Engineering, Part C: Methods
    Conclusion: We have found adenovirus to be the most efficient of the vector systems tested for gene delivery to EPCs, an effect that is mediated almost entirely by one of two ...
  • Harnessing Systems Biology Approaches to Engineer Functional...
    Lauren S. Sefcik, Jennifer L. Wilson, Jason A. Papin, Edward A. Botchwey
    Tissue Engineering, Part B: Reviews
    Most pro-angiogenic clinical trials to date have focused on increasing neovascularization via the delivery of a single growth factor or gene. Alternatively, a focus on the ...
  • Direct Gene Therapy for Bone Regeneration: Gene Delivery, Animal...
    Gadi Pelled, Ayelet Ben-Arav, Colleen Hock, David G. Reynolds, Cemal Yazici, Yoram Zilberman, Zulma Gazit, Hani Awad, Dan Gazit, Edward M. Schwarz
    Tissue Engineering, Part B: Reviews
    Direct Gene Therapy for Bone Regeneration: Gene Delivery, Animal Models, and Outcome Measures Tissue Engineering, Part B: Reviews While various problems with bone healing remain, ...
  • Vascular Endothelial Growth Factor Inhibits Bone Morphogenetic...
    Björn H. Schönmeyr, Marc Soares, Tomer Avraham, Nicholas W. Clavin, Fredrik Gewalli, Babak J. Mehrara
    Tissue Engineering, Part A
    Alterations in gene and protein expression in vitro as well as bone formation in vivo were ... require careful optimization and precise delivery of growth factors for maximal bone ...

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