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  • Nuevolution, HHMI, Lexicon, and Duke Form GPCR-Focused Collaboration
    mechanism of action of a specified G protein-coupled receptor (GPCR) drug target. ... with certain novel properties against the GPCR drug target. "We have used the Chemetics ...
    8-12-2013
  • Membrane Protein Monoclonal Antibodies
    to the extracellular domain of the GPCR. Therapeutic antibodies are a key driving ... CDR and the extracellular region of the GPCR ADORA2A. The size of the antibody ...
    8-1-2013
  • Calcium Assay Kits
    Our commitment to innovation is driven by the needs of our customers and the objectives of their research programs. FLIPR® Calcium 6 assay kits address a range of GPCR and ion ...
    6-15-2013
  • Diversifying Your Antibody Portfolio
    ... A robust humoral immune response in FcRn transgenic mice demonstrated to overcome the animal's immune tolerance as antibody titers generated against a GPCR-related mouse ...
    5-15-2013
  • Forest Labs Bets Up To $460M on Trevena Heart Failure Drug
    Trevena, which specializes in developing G-protein coupled receptor- (GPCR-) biased ... validates our biased ligand approach to GPCR drug discovery," Maxine Gowen, Trevena's ...
    5-9-2013
  • Exploring GPCRs as Therapeutic Targets
    A number of distinguished speakers will present their latest GPCR research at the GPCR Colloquium at the "American Society for Pharmacology and Experimental Therapeutics" meeting. ...
    4-15-2013
  • Isolating Membrane Protein Antibodies
    ... containing the GPCR CXCR4 were used to pan a naïve library using optimized protocols. ... antibodies against the seven-transmembrane GPCR CXCR4. A large number of individual phage ...
    3-15-2013
  • Receptos Licenses AbbVie Antibody for Co-Development
    ... Its lead drug development program, RPC1063, is an oral, once-daily modulator of the sphingosine 1-phosphate 1 receptor (S1P1R) pathway, a G protein-coupled receptor (GPCR) target ...
    3-13-2013
  • A Good Day for Milestones
    by determining a novel protein crystal structure of a GPCR drug discovery target. ... , when Ono made a deal to access Receptos' GPCR structure determination technology ...
    3-7-2013
  • MorphoSys Strikes GCPR Deal with Heptares
    Heptares will generate stabilized receptors (StaRs®) for a set of GPCR disease targets ... one therapeutic antibody created by MorphoSys against a GPCR target selected by Heptares. ...
    2-13-2013
  • Prexton Licenses Domain's Parkinson's Disease Drug
    payment and research funding, and was eligible for up to €132 million in milestones for the first two products. mGluR4 is a glutamate receptor, member of the GPCR family. ...
    1-22-2013
  • GPCRs Targeted in Heptares/Cubist Collab
    The collaborative research will focus on up to two GPCR drug targets to be selected by ... Cubist also has the option to nominate a second GPCR target at a later point in the ...
    1-7-2013
  • Novel Strategies for Cell-Based Assays
    Say you have a G-protein coupled receptor (GPCR) of unknown function-with this assay you ... Xavier Leroy, Ph.D., leads the research program in GPCR drug discovery at Actelion ...
    1-1-2013
  • Heptares Brings GPCR Knowledge to European Consortium
    protein kinases, proteases, and G protein-coupled receptors (GPCR)-by providing it with access to expertise and stabilized GPCRs as well as its broader GPCR discovery platform. ...
    11-29-2012
  • Developing Chicken-Derived mAbs
    monoclonal antibodies against undisclosed therapeutic GPCR and ion channel targets. ... antibodies against undisclosed therapeutic GPCR and ion channel targets. Developing ...
    11-16-2012
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    Journal Articles

  • 1,536-Well Assay Development and Screening Using Whole Cell Displaceme...
    Douglas S. Auld, David A. Dunn, John M. Lehrach, Paul McCoy, Rob Swanson
    ASSAY and Drug Development Technologies
    ASSAY and Drug Development Technologies A screen of a GPCR against Pharmacopeia's combinatorial libraries was performed using 1,536-well plates in a 1.5-µl assay volume with an ...
  • Emerging Concepts of Guanine Nucleotide-Binding Protein-Coupled...
    Richard M. Eglen, Roger Bosse, Terry Reisine
    ASSAY and Drug Development Technologies
    Emerging Concepts of Guanine Nucleotide-Binding Protein-Coupled Receptor (GPCR) Function and Implications for High Throughput Screening ASSAY and Drug Development Technologies
  • CypHer 5: A Generic Approach for Measuring the Activation and...
    Elaine J. Adie, Michael J. Francis, June Davies, Lynne Smith, Angela Marenghi, Catherine Hather, Karen Hadingham, N. Paul Michael, Graeme Milligan, Stephen Game
    ASSAY and Drug Development Technologies
    CypHer 5 provides a generic tool to measure GPCR activation in a live cell, homogeneous assay format, and may be equally suitable for detecting activation of other classes of cell ...
  • Characterization of CHO Cells Stably Expressing a Gα 16/z Chimera...
    David C. New, Yung H. Wong
    ASSAY and Drug Development Technologies
    requires the use of high throughput assays that are applicable to all GPCR subtypes. ... We have generated nine cell lines each stably expressing 16z25 and a GPCR. All cell lines ...

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