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Search Results - GPCR
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  • Diversifying Your Antibody Portfolio
    ... A robust humoral immune response in FcRn transgenic mice demonstrated to overcome the animal's immune tolerance as antibody titers generated against a GPCR-related mouse ...
    5-15-2013
  • Forest Labs Bets Up To $460M on Trevena Heart Failure Drug
    Trevena, which specializes in developing G-protein coupled receptor- (GPCR-) biased ... validates our biased ligand approach to GPCR drug discovery," Maxine Gowen, Trevena's ...
    5-9-2013
  • Exploring GPCRs as Therapeutic Targets
    A number of distinguished speakers will present their latest GPCR research at the GPCR Colloquium at the "American Society for Pharmacology and Experimental Therapeutics" meeting. ...
    4-15-2013
  • Isolating Membrane Protein Antibodies
    ... containing the GPCR CXCR4 were used to pan a naïve library using optimized protocols. ... antibodies against the seven-transmembrane GPCR CXCR4. A large number of individual phage ...
    3-15-2013
  • Receptos Licenses AbbVie Antibody for Co-Development
    ... Its lead drug development program, RPC1063, is an oral, once-daily modulator of the sphingosine 1-phosphate 1 receptor (S1P1R) pathway, a G protein-coupled receptor (GPCR) target ...
    3-13-2013
  • A Good Day for Milestones
    by determining a novel protein crystal structure of a GPCR drug discovery target. ... , when Ono made a deal to access Receptos' GPCR structure determination technology ...
    3-7-2013
  • MorphoSys Strikes GCPR Deal with Heptares
    Heptares will generate stabilized receptors (StaRs®) for a set of GPCR disease targets ... one therapeutic antibody created by MorphoSys against a GPCR target selected by Heptares. ...
    2-13-2013
  • Prexton Licenses Domain's Parkinson's Disease Drug
    payment and research funding, and was eligible for up to €132 million in milestones for the first two products. mGluR4 is a glutamate receptor, member of the GPCR family. ...
    1-22-2013
  • GPCRs Targeted in Heptares/Cubist Collab
    The collaborative research will focus on up to two GPCR drug targets to be selected by ... Cubist also has the option to nominate a second GPCR target at a later point in the ...
    1-7-2013
  • Novel Strategies for Cell-Based Assays
    Say you have a G-protein coupled receptor (GPCR) of unknown function-with this assay you ... Xavier Leroy, Ph.D., leads the research program in GPCR drug discovery at Actelion ...
    1-1-2013
  • Cell-Based Assays for Enhanced Safety, Activity, and Target Specificit...
    The value of utilizing cell-based kinase assays as a functional read-out of GPCR pathway activation will also be explored. In This Webinar You Will Discover Why cell-based assays ...
    12-5-2012
  • Heptares Brings GPCR Knowledge to European Consortium
    protein kinases, proteases, and G protein-coupled receptors (GPCR)-by providing it with access to expertise and stabilized GPCRs as well as its broader GPCR discovery platform. ...
    11-29-2012
  • Developing Chicken-Derived mAbs
    monoclonal antibodies against undisclosed therapeutic GPCR and ion channel targets. ... antibodies against undisclosed therapeutic GPCR and ion channel targets. Developing ...
    11-16-2012
  • DiscoveRx Acquires BioSeek
    for drug discoverers, including DiscoveRx' GPCR, Kinase, and NHR assay solutions using its ... The deal combines DiscoveRx's GPCR, Kinase, and NHR assay solutions with BioSeek's BioMAP ...
    11-7-2012
  • Firms Collaborate on Small Molecule GPCR Drugs
    Through the partnership Domain will use its DTect-All(tm) GPCR drug discovery platform and ... and a fluorescent ligand selected from Domain's library of GPCR frequent hitter probes. ...
    10-23-2012
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    Journal Articles

  • Sphingosine 1-Phosphate Regulation of Extracellular Signal-Regulated...
    Alayna Rodgers, David Mormeneo, Jaclyn S. Long, Antonio Delgado, Nigel J. Pyne, Susan Pyne
    Stem Cells and Development
    The S1P-dependent activation of ERK-1/2 was sensitive to inhibition by pertussis toxin (uncouples the G-protein, Gi from GPCR), bisindolylmaleimide I (PKC inhibitor), and PP2 ...
  • A Murine Monoclonal Antibody That Binds N-Terminal Extracellular...
    Takeshi Sangawa, Terukazu Nogi, Junichi Takagi
    Hybridoma
    Abstract A monoclonal antibody that recognizes native G protein coupled receptors (GPCR) is generally difficult to obtain. Protease-activated receptor-4 (PAR4) is a GPCR that plays ...
  • Electroporation-Aided DNA Immunization Generates Polyclonal Antibodies...
    Bertrand Allard, Fabienne Priam, Frédérique Deshayes, Frédéric Ducancel, Didier Boquet, Anne Wijkhuisen, Jean-Yves Couraud
    DNA and Cell Biology
    DNA and Cell Biology Endothelin B receptor (ETBR) is a G protein-coupled receptor (GPCR) specific for endothelin peptides (including endothelin-1, ET1), which mediates a variety of ...
  • GPCRs Promote the Release of Zinc Ions Mediated by nNOS/NO and...
    Pilar Sánchez-Blázquez, María Rodríguez-Muñoz, Concha Bailón, Javier Garzón, Pilar Sanchez-Blazquez, Maria Rodriguez-Munoz, Concha Bailon
    Antioxidants & Redox Signaling
    terminus or the third internal loop of the GPCR. Innovation: A series of GPCRs share an ... Redox mechanisms are crucial for the successful propagation of GPCR signals in neurons. ...

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