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  • What Junk DNA? It's an Operating System
    from the Encyclopedia of DNA Elements (ENCODE), a public research consortium launched ... , Genome Biology , and Genome Research , ENCODE indicated that the biologically active ...
    8-6-2013
  • CRISPR/Cas Comes of Age-Almost
    Cas genes encode a family of proteins that carry functional domains typical of nucleases, helicases, polymerases, and polynucleotide-binding proteins. To date, investigators have ...
    7-24-2013
  • Unraveling the Transcriptome
    ... lack one or several introns, or contain premature stop codons and, as a result, do not encode functional proteins. Nevertheless, intron-spanning RNA reads may align to pseudogenes. ...
    7-1-2013
  • Genome 2.0: First Form, Now Function
    What does most of the genome-80% of which was recently defined by the ENCODE project to be functional in some way-do? What is normal genetic variation? Which variations will lead ...
    6-15-2013
  • Liquid Handling Needs a Helping Hand
    ... But the hope is that perhaps 1 in 1,000 of these truncated constructs will actually encode the piece of protein that folds up into a stable domain. The plasmids are all made in a ...
    6-15-2013
  • Library Format for Bioengineering
    Libraries on the lower end of the mutation spectrum will encode many wild-type sequences. Even though in principle the theoretical size of a random mutagenesis library is very ...
    4-15-2013
  • Super-Enhancer Discovery Opens New Cancer Research Doors
    To date, a vast body of research, including that of the recently described ENCODE (Encyclopedia of DNA Elements) project, has identified more than one million enhancers or ...
    4-11-2013
  • DNA @ 60: Where Are We Headed from Here?
    Rashid Bashir describes the outlook for nano-based next-gen sequencing tools ( Direct DNA Sequencing Using Nanopore Sensors ) while Dr. Ian Dunham takes a look at ENCODE ( ENCODE-i...
    4-1-2013
  • ENCODE-ing the Future
    The ENCODE project was established to utilize and integrate multiple techniques to help ... The Encyclopedia of DNA Elements (ENCODE) project aimed to integrate multiple approaches ...
    4-1-2013
  • Querying the Cancer Transcriptome
    and dynamic transcriptional patterns unveiled by the ENCyclopedia of DNA Elements (ENCODE) project, together with the finding that less than 2% of the transcriptional output of ...
    4-1-2013
  • GEN Celebrates Publication of Historic Watson-Crick DNA Structure...
    Rashid Bashir describes the outlook for nano-based nextgen sequencing tools Dr. Ian Dunham takes a close look at the ENCODE public research consortium Dr. Richard Stein writes ...
    4-1-2013
  • WATCH: What's Your Junk DNA Worth?
    why your junk DNA may actually be quite valuable. Through the ENCODE project, scientists have recently revealed that junk DNA is in fact useful in ways we hadn't understood. ...
    3-28-2013
  • Molecular Roots of Down Syndrome Unraveled
    Xu and his colleagues wondered how Down syndrome and low SNX27 are connected. Could the extra chromosome 21 encode something that affects SNX27 levels? They suspected microRNAs, ...
    3-25-2013
  • Footprint-Free, Site-Specific Gene Editing
    ... DNA transposons, sometimes called "jumping genes", are naturally occurring mobile DNA elements that encode the gene for an enzyme, a transposase, that is flanked by a pair of ...
    3-1-2013
  • Next-Generation Sequencing in the Clinic
    ... What will be the influence of ENCODE [see "The Encyclopedia of DNA Elements (ENCODE) Consortium", below] on NGS efforts and what does it mean for exome sequencing in cancer ...
    2-13-2013
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    Journal Articles

  • Viral Interference with Antigen Presentation to CD8 + T Cells...
    Amelia K. Pinto, Ann B. Hill
    Viral Immunology
    Cytomegaloviruses (CMV), in common with other Herpesviruses, establish lifelong persistence in their hosts. These highly host-specific viruses each encode viral genes that ...
  • Mechanisms of Reovirus-Induced Cell Death and Tissue Injury:...
    P. Clarke, R.L. DeBiasi, R. Goody, C.C. Hoyt, S. Richardson-Burns, K.L. Tyler
    Viral Immunology
    Reoviruses have provided insight into the roles played by specific viral genes and the proteins they encode in virus-induced cell death and tissue injury. Apoptosis is a major ...
  • A Novel Mutation in the Thyrotropin (Thyroid-Stimulating Hormone...
    A. Jeziorowska, B. Pniewska-Siark, E. Brzezianska, D. Pastuszak-Lewandoska, A. Lewinski
    Thyroid
    A study of some familial cases has allowed identification of mutations in several known genes, including that encode the thyroid-stimulating hormone receptor (TSHR). We report a ...
  • Biological Network Querying Techniques: Analysis and Comparison
    Valeria Fionda, Luigi Palopoli
    Journal of Computational Biology
    These tools leverage Biological Networks as a formal model to encode molecular interactions. Biological networks can be fed as input to graph-based techniques useful to infer new ...

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