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  • Library Format for Bioengineering
    Libraries on the lower end of the mutation spectrum will encode many wild-type sequences. Even though in principle the theoretical size of a random mutagenesis library is very ...
    4-15-2013
  • Super-Enhancer Discovery Opens New Cancer Research Doors
    To date, a vast body of research, including that of the recently described ENCODE (Encyclopedia of DNA Elements) project, has identified more than one million enhancers or ...
    4-11-2013
  • DNA @ 60: Where Are We Headed from Here?
    Rashid Bashir describes the outlook for nano-based next-gen sequencing tools ( Direct DNA Sequencing Using Nanopore Sensors ) while Dr. Ian Dunham takes a look at ENCODE ( ENCODE-i...
    4-1-2013
  • ENCODE-ing the Future
    The ENCODE project was established to utilize and integrate multiple techniques to help ... The Encyclopedia of DNA Elements (ENCODE) project aimed to integrate multiple approaches ...
    4-1-2013
  • Querying the Cancer Transcriptome
    and dynamic transcriptional patterns unveiled by the ENCyclopedia of DNA Elements (ENCODE) project, together with the finding that less than 2% of the transcriptional output of ...
    4-1-2013
  • GEN Celebrates Publication of Historic Watson-Crick DNA Structure...
    Rashid Bashir describes the outlook for nano-based nextgen sequencing tools Dr. Ian Dunham takes a close look at the ENCODE public research consortium Dr. Richard Stein writes ...
    4-1-2013
  • WATCH: What's Your Junk DNA Worth?
    why your junk DNA may actually be quite valuable. Through the ENCODE project, scientists have recently revealed that junk DNA is in fact useful in ways we hadn't understood. ...
    3-28-2013
  • Molecular Roots of Down Syndrome Unraveled
    Xu and his colleagues wondered how Down syndrome and low SNX27 are connected. Could the extra chromosome 21 encode something that affects SNX27 levels? They suspected microRNAs, ...
    3-25-2013
  • Footprint-Free, Site-Specific Gene Editing
    ... DNA transposons, sometimes called "jumping genes", are naturally occurring mobile DNA elements that encode the gene for an enzyme, a transposase, that is flanked by a pair of ...
    3-1-2013
  • Next-Generation Sequencing in the Clinic
    ... What will be the influence of ENCODE [see "The Encyclopedia of DNA Elements (ENCODE) Consortium", below] on NGS efforts and what does it mean for exome sequencing in cancer ...
    2-13-2013
  • Epigenetics: Promising Field Delivers
    ... By using the ENCODE data to examine the genomic distribution of hypomethylation, the investigators found an enrichment of this modification at enhancer regions during both B-cell ...
    1-15-2013
  • Colby Enters Cancer Immunotherapy Product License Deal
    A patient's immune system is first "primed" by DNA plasmids that are injected directly into accessible, nondiseased, superficial inguinal lymph nodes. These plasmids encode ...
    11-13-2012
  • Novel DNA Assembly Strategies
    ... The approaches presented here enable researchers to readily design, construct, edit, and mobilize plasmids with enough capacity to encode complex genetic pathways. Size and ...
    11-1-2012
  • RNA Analysis Unearths Invaluable Insights
    ... Brenner. While examining the human genes that encode SR splicing regulators, a family of structurally and phylogenetically related positive regulators of constitutive alternative ...
    10-15-2012
  • Optimizing Protein Expression
    ... Consequently, genes that encode these heterologous protein sequences are inserted directly into the yeast genome with a controlled copy number. Time-course experiments evaluate ...
    9-15-2012
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    Journal Articles

  • Molecular Mechanisms of Biofilm Infection: Biofilm Virulence...
    Priscilla L. Phillips, Gregory S. Schultz
    Advances in Wound Care
    The Problem: There is a need to identify the genes that encode biofilm virulence factors and understand how these factors function to enable bacteria to successfully establish ...
  • Genetic Diversity of Enterococci Harboring the High-Level Gentamicin...
    Shojiro Watanabe, Nobumichi Kobayashi, Dianelys Quiñones, Shigeo Nagashima, Nobuyuki Uehara, Naoki Watanabe
    Microbial Drug Resistance
    Prevalence of high-level gentamicin resistance genes aac(6')-Ie-aph(2?)-Ia and aph(2?)-Ie, which encode distinct aminoglycoside-modifying enzymes, was analyzed for a total of 1128 ...
  • The Prevalence of the OqxAB Multidrug Efflux Pump amongst Olaquindox...
    Lars Hestbjerg Hansen, Søren J. Sørensen, Helle S. Jørgensen, Lars B. Jensen
    Microbial Drug Resistance
    Recently, we isolated a plasmid (pOLA52) conferring resistance to olaquindox from swine manure. On this plasmid, the oqxA and oqxB genes encode an RND-family multidrug efflux pump, ...
  • Stem Cell-Related Gene Expression in Clonal Populations of Mesenchymal...
    Shobha Mareddy, Navdeep Dhaliwal, Ross Crawford, Yin Xiao
    Tissue Engineering, Part A
    A group of 10 genes were commonly overrepresented in the fast-growing stem cell clones. These included genes that encode proteins involved in the maintenance of embryonic and ...

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