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Search Results - EPO (Erythropoietin)
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  • Xenon Pays Isis $2M for Exclusive License to Co-Developed Antisense...
    kidney disease who are intolerant of or who are poor responders to erythropoietin therapy. ... to patients with ACD through a novel non-Epo receptor-based mechanism and we are looking ...
    6-10-2013
  • Mammalian Transient Transfection System
    ... Recombinant erythropoietin (EPO) was tested for biological activity using a TF-1 cell-based proliferation assay. The biological activity of EPO was highly similar for both ...
    10-1-2012
  • Speeding the Selection of Biologically Active Antibodies
    erythropoietin agonist antibodies. Firstly, more traditional techniques were used to rifle through an antibody library to identify thousands of antibodies that bind to the EPO ...
    9-12-2012
  • Going for Gold: Finding Doping in Sports
    can be detected via GC/MS or LC/MS, drugs that mimic naturally occurring molecules such as erythropoietin (EPO) or human growth hormone (hGH) prove to be a little more difficult. ...
    9-4-2012
  • Olympic Anti-Doping Goes for Gold
    and boxing-but which dilutes urine enough to complicate detection of other drugs-and erythropoietin (EPO), a hormone that boosts red blood cells, enabling improved oxygen flow. ...
    9-1-2012
  • Biosimilars Now Just About Ready to Roll
    ... Hospira began Phase III trials in January to compare the safety and efficacy of its biosimilar erythropoietin (EPO) and the reference product, Amgen's Epogen, in patients with ...
    9-1-2012
  • Olympic Anti-Doping Goes for Gold
    and boxing-but which dilutes urine enough to complicate detection of other drugs-and erythropoietin (EPO), a hormone that boosts red blood cells, enabling improved oxygen flow. ...
    8-8-2012
  • Proposed Standards for Immunogenicity Testing
    ... A slight change in the manufacture of epoetin resulted in the production of anti-EPO antibodies in some patients. These antibodies caused a suppression of endogenous erythropoietin...
    6-15-2012
  • Firms Are Upping the Stakes on mAb Biosimilar Development
    Amgen's Epogen, a recombinant form of erythropoietin, and Neupogen, a recombinant human ... products like EPO were the clear winners and darlings of the biopharmaceutical industry. ...
    12-16-2011
  • Directing Cell-Signaling Research
    ... Take, for example, the cytokine and growth factor erythropoietin (EPO), which is FDA approved to treat anemia. EPO stimulates AKT, and Dr. Maiese has shown that many of the ...
    11-1-2011
  • Secrecy Surrounds the Development of Tests to Detect Doping
    Cycling has led the sports pack with a legendary bad record for doping, rivaling only baseball in its use of performance-enhancing drugs, most notably erythropoietin (EPO). The ...
    8-4-2011
  • Celgene Pays Acceleron $25M to Add Second Candidate to Anemia...
    In preclinical studies ACE-536 promoted red blood cell (RBC) formation in the absence of erythropoietin (EPO) signaling, had distinct effects from EPO on RBC differentiation, and ...
    8-3-2011
  • Prolor Licenses Reversible PEGylation Technology from Weizmann...
    ... These include: an interferon candidate IFN-β-CTP (MOD-9013); Factor VIIa-CTP (MOD-5023); an erythropoietin candidate EPO-CTP (MOD-7023); GLP-1-CTP (MOD-1001); and an obesity ...
    1-18-2011
  • Immunogenicity Testing Proves Invaluable
    ... For example, the clinically significant immunogenicity problems now widely acknowledged for erythropoietin (EPO) could not have been revealed even by the relatively large, ...
    9-1-2010
  • Spotlight on Opportunities & Innovations
    ... groups to establish a biosimilars pathway in the U.S. Currently, the top five Medicare expenditures are for biologicals, with EPO (erythropoietin) alone accounting for $2 billion. ...
    7-1-2010
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    Journal Articles

  • Hypoxia: Adapting to High Altitude by Mutating EPAS-1 , the Gene...
    Martha C. Tissot van Patot, Max Gassmann
    High Altitude Medicine & Biology
    Unexpectedly, the responsible mutation(s) reducing red blood cell production do not involve either the gene encoding the blood hormone erythropoietin (Epo), or the corresponding ...
  • Erythropoietin Potentiates EDHF-Mediated Dilations in Rat Middle...
    Nadeem I. Shafi, Jon Andresen, Sean P. Marrelli, Robert M. Bryan
    Journal of Neurotrauma
    Erythropoietin Potentiates EDHF-Mediated Dilations in Rat Middle Cerebral Arteries Journal of Neurotrauma ABSTRACT The neuroprotective effects of exogenous erythropoietin (EPO) in ...
  • Impact of Thyroid Dysfunction on Erythropoietin Dosage in Hemodialysis...
    Yee Yung Ng, Hong Da Lin, Shiao Chi Wu, Chih Yu Yang, Wu Chang Yang, Hung Hsiang Liou, Fen Hsiang Hu, Chun Cheng Hou, Su Shan Tseng, Nai Yung Ku, Nien Yung Hsiao, Wen Chieh Wu, Hsing Meng Tu, Tse-Jen Lien, Chung Ching Lee, Kwong Kee Tsang, Chen Seng Cheng, Jean Hu, Ru Ping Lin
    Thyroid
    Therefore, the impact of thyroid diseases on erythropoietin (EPO) dosage in HD patients is not well defined. This study was to evaluate the relationship between the dose of EPO and ...
  • Bone Marrow Mesenchymal Stem Cells in Patients with Beta Thalassemia...
    Ceren Aksoy, Ali Guliyev, Emine Kilic, Duygu Uckan, Feride Severcan
    Stem Cells and Development
    These alterations were also supported by ELISA results of erythropoietin (EPO) and growth differentiation factor (GDF15) in bone marrow plasma samples as a reflection of IE and by ...

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