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  • Pharma Touting Phase II/III Wins in Run-Up to ASCO
    ... The firm today said that afatinib, which was evaluated in the LUX-Lung 6 trial as a first-line treatment in Asian patients with EGFR mutation-positive advanced NSCLC, has met its ...
    5-16-2013
  • FDA Approves Roche EGFR Mutation CDx for NSCLC
    approved Roche Molecular Systems' cobas® EGFR Mutation Test as a companion diagnostic ... whose tumors showed EGFR exon 19 deletions or exon 21 (L858R) substitution mutations. ...
    5-15-2013
  • Amgen Forms Joint Venture to Sell Vectibix in China
    Vectibix is a monoclonal antibody that binds specifically to the epidermal growth factor receptor (EGFR). On Tuesday, Amgen reported results from its Phase III "ASPECCT ('763)" ...
    5-10-2013
  • Companion Diagnostics: 52 Pick-Up
    ... DAKO EGFR PharmDx Kit Sponsor/Developer: Agilent Technologies (Dako) Intended Use/... identify epidermal growth factor receptor (EGFR) expression in normal and neoplastic ...
    5-9-2013
  • Cancer Diagnostics, Pushing the Boundaries
    ... Both "may be of important for clinical decision-making because loss of PTEN is associated with resistance to anti-EGFR therapies," they explained. Using a Sanger sequencing assay ...
    5-8-2013
  • The Tumor Microenvironment as a Drug Target, Part II
    ... In in vivo or in vitro cancer cells, RhoB acts as a tumor suppressor, restricting epidermal growth factor receptor (EGFR) on the cell surface as well as Akt signaling. But ...
    5-7-2013
  • Gene Expression Analysis in Living Cells
    ... correlates to RT-PCR data. mRNA levels of EGFR RNA (A) in HeLa and MCF-7 cells and FGF2 ... measured the levels of two mRNA targets, EGFR and FGF2, in cell types that show ...
    5-1-2013
  • Detecting Acquired Drug Resistance in Cancer
    identifying an EGFR mutation in plasma, a mutation not found in an initial ovarian biopsy. ... detection of acquired resistance to anti-EGFR therapies in colorectal cancer patients. ...
    4-29-2013
  • Literature Review: Which Drug Combination Will Unlock Triple...
    Researchers describe a strategy for treating TNBC that combines noncompetitive antibodies to achieve degradation of EGFR and tumor inhibition. Figure 1. Anti-EGFR antibodies ...
    4-25-2013
  • Pathway Analysis to Decipher Data
    ... mRNA expression analyses, the fourth column represents copy number variation of EGFR. The right-most column represents Kaplan-Meier plots for "days to death" based on the EGFR data. ...
    4-15-2013
  • Top 20 Best-Selling Drugs Approved and Launched During 2012
    ... irinotecan-based chemotherapy, an anti-VEGF therapy, and, if KRAS wild type, an anti-EGFR therapy Date of FDA approval: September 27, 2012 #6. Stribild(tm) (elvitegravir, ...
    4-4-2013
  • Women and Smoking
    in specific cancer genes such as p53, epidermal growth factor receptor (EGFR), and K-ras. ... 3,026 lung adenocarcinomas for the major EGFR mutations (exon 19 deletions and L858R) ...
    4-3-2013
  • Personalized Medicine: From Biomarkers to Companion Diagnostics
    A number of biomarkers, such as KRAS and EGFR mutations, could only be established after a ... were asked to select patients with a positive EGFR biomarker or a KRAS biomarker. ...
    3-26-2013
  • Personalized Medicine: Translation of Concepts
    ... diagnosed with non-small cell lung cancer, but patients with a specific EGFR mutation. ... Gefitinib is therefore indicated for patients with tumours showing specific EGFR ...
    3-19-2013
  • Gene Expression Analysis Making Inroads
    ... However, since H-Ras is hardly mutated in human gliomas, this oncogene only serves as a surrogate for EGFR, which is overexpressed in gliomas (EGFR amplification leads to Ras ...
    3-15-2013
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    Journal Articles

  • Combinatorial Human Progenitor Cell Transplantation Optimizes...
    Gillian I. Bell, Michael T. Meschino, Jennifer M. Hughes-Large, Heather C. Broughton, Anargyros Xenocostas, David A. Hess
    Stem Cells and Development
    Regenerative MSCs showed increased expression of matrix metalloproteases, epidermal growth factor receptor (EGFR)-activating ligands, and downstream effectors of Wnt signaling. ...
  • Kidney Dysfunction, Cardiorespiratory Fitness, and the Risk of...
    Martha Gulati, Henry R. Black, Morton F. Arnsdorf, Leslee J. Shaw, George L. Bakris
    Journal of Women's Health
    Serum creatinine (Cr) was used to estimate glomerular filtration rate (eGFR), and spot ... Mean Cr was 1.11±0.14?mg/dL, and mean eGFR was 53.7±8.3?mL/min/1.73?m2 at baseline. The ...
  • Molecular and Genotypic Characterization of Human Thyroid Follicular...
    Ana Margarida Meireles, Ana Preto, Ana Sofia Rocha, Ana Paula Rebocho, Valdemar Máximo, Isabel Pereira-Castro, Severina Moreira, Tália Feijão, Tiago Botelho, Ricardo Marques, Vítor Trovisco, Luís Cirnes, Cíntia Alves, Sérgia Velho, Paula Soares, Manuel Sobrinho-Simões
    Thyroid
    Considering the putative relevance in general carcinogenesis, we have also studied other molecules such as EGFR, PI3K, RAF-1, and THRB. To determine the genetic identity of the ...
  • Predicting Chronic Kidney Disease Outcomes: Are Two Estimated...
    Jason DeVille, David H. Smith, Eric S. Johnson, Xiuhai Yang, Amanda F. Petrik, Jessica R. Weiss, Micah L. Thorp
    Population Health Management
    of CKD or require RRT. Methods Our objective was to determine whether 2 eGFR tests were better than 1 eGFR as a predictor of renal replacement therapy, CKD progression or death. ...

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