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  • Cancer Diagnostics, Pushing the Boundaries
    progression, prognosis, heterogeneity, therapeutic options, and drug-resistance of cancers and tumor types are an increasingly important part of the clinician's diagnostic toolbox. ...
    5-8-2013
  • Harnessing the Power of Kinase Inhibitors
    ... by preventing resistance to targeted treatments by applying the Nanocyclix platform. ... -3. The researchers used structure-based drug design to improve potency and various ...
    5-8-2013
  • AZ Giving Way to Early-Stage Biopharmas in Cheshire
    resistance to antibiotics and new medicines to tackle viral infections: "A particular focus will be hard-to-treat infections. These include the growing threat of drug-resista...
    5-7-2013
  • The Tumor Microenvironment as a Drug Target, Part II
    And they note that although cancer drug development has historically focused on targeting ... cancer, CAFs not only promote tumor progression but also induce therapeutic resistance. ...
    5-7-2013
  • Metabolomics Advances Reshape Dx Arena
    ... Further investigations shed light on the underlying mechanisms of acquired resistance to treatment with ALK tyrosine kinase inhibitors. PTMScan Direct Profiling of drug-resistant ...
    5-1-2013
  • The Tumor Microenvironment as a Drug Target: Chasing Slippery...
    ... and maturity of a blood vessel, thereby impacting how well it delivers drug to a tumor. ... epithelial counterparts but also less likely to acquire resistance to a cytotoxic agent. ...
    5-1-2013
  • Ascletis Obtains Chinese Rights to Janssen HIV Treatment
    we believe that TMC310911 has the potential to offer a new standard of care, especially for HIV-infected patients exhibiting multi-drug resistance to current PIs," Dr. Wu said. ...
    4-30-2013
  • Detecting Acquired Drug Resistance in Cancer
    say, reflects the complexity of the disease process coupled with an inability to properly guide the use of available therapeutics, and the development of tumor drug resistance. ...
    4-29-2013
  • Hormone Holds Promise for Replacing Insulin Injections
    proliferation in other mouse models of insulin resistance, as well as during gestation. ... As a result, Janssen received exclusive access to a series of drug candidates designed to ...
    4-26-2013
  • Scientists Prime "Smartphone-Like" POC Malaria Diagnostic for...
    prescription of effective antimalarial drugs. "Placing a full malaria screen with drug resistance status based on accurate DNA analysis in the palm of a health professional's ...
    4-24-2013
  • Horizon, AstraZeneca Seek Kinase-Targeting Cancer Drugs
    K-Ras is mutated in up to 40% of all cancer types causing resistance to many of the ... greatly from the use of Horizon's drug discovery toolbox to first exquisitely ...
    4-22-2013
  • Pathway Analysis to Decipher Data
    ... that may be useful for addressing unmet clinical needs, especially relating to drug resistance, according to Joseph Lehar, Ph.D., director of bioinformatics, oncology ...
    4-15-2013
  • Single-Use Bioreactor Roundup
    ... It requires mastering high-quality welding to ensure sterility and long-term resistance. ... use of single-use bioreactors in commercial drug manufacturing will grow significantly. ...
    4-15-2013
  • Yeast Strain Rises to Fight Malaria
    with another antimalarial drug to create the antimalarial ACT-a process that partners say reduces the chance that the malaria parasite will develop resistance to artemisinin. ...
    4-11-2013
  • Five Japanese Pharmas Join Drug-Development Fund
    diseases. GHIT parallels public-private drug development efforts elsewhere worldwide, ... Commission to fund research into resistance to antibiotics and other health areas ...
    4-8-2013
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    Journal Articles

  • Methicillin-Resistant Staphylococcus pseudintermedius in Sweden
    Stefan Börjesson, Annica Landén, Martin Bergström, Ulrika Grönlund Andersson, Ulrika Grönlund-Andersson
    Microbial Drug Resistance
    Methicillin-Resistant Staphylococcus pseudintermedius in Sweden Microbial Drug Resistance Staphylococcus pseudintermedius is an opportunistic pathogen that is one of the most ...
  • Novel Chimerical Endolysins with Broad Antimicrobial Activity...
    Sofia Fernandes, Daniela Proença, Cátia Cantante, Filipa Antunes Silva, Clara Leandro, Sara Lourenço, Catarina Milheiriço, Hermínia de Lencastre, Patrícia Cavaco-Silva, Madalena Pimentel, Carlos São-José, Herminia de Lencastre, Carlos Sao-Jose
    Microbial Drug Resistance
    Novel Chimerical Endolysins with Broad Antimicrobial Activity Against Methicillin-Resistant Staphylococcus aureus Microbial Drug Resistance Due to their bacterial lytic action, ...
  • Phage Endolysins with Broad Antimicrobial Activity Against Enterococcu...
    Daniela Proença, Sofia Fernandes, Clara Leandro, Filipa Antunes Silva, Sofia Santos, Fátima Lopes, Rosario Mato, Patrícia Cavaco-Silva, Madalena Pimentel, Carlos São-José, Carlos Sao-Jose
    Microbial Drug Resistance
    Phage Endolysins with Broad Antimicrobial Activity Against Enterococcus faecalis Clinical Strains Microbial Drug Resistance Increasing antibiotic resistance of bacterial pathogens ...
  • Mutations in Streptococcus pneumoniae Penicillin-Binding Protein...
    Patrick Maurer, Katya Todorova, Julia Sauerbier, Regine Hakenbeck
    Microbial Drug Resistance
    Microbial Drug Resistance PBP2x mutations that occur during the selection with beta-lactams are located within the central penicillin-binding/transpeptidase domain, and are ...

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