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Search Results - Downstream Processing
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  • Downstream Processing
    Cambridge MA UNITED STATES shortprograms.mit.edu/dsp
    8-5-2013
  • Improving Proteomics Approaches
    Gravity entails very long sample prep times and is unsuitable for parallel processing. ... Subsequently, the noncovalent interactions have emerged as central in events downstream ...
    5-15-2013
  • Productivity Boost for Biopurification
    Twin-Column Ultra-High Resolution Chromatography Chromatography is the most important unit operation in the downstream processing of biopharmaceuticals. In most cases, at least two ...
    5-15-2013
  • Separation of Therapeutic Biomolecules
    of proteins was the focus of a series of talks at Tosoh Bioscience's recent "HIC/RPC Bioseparation Conference: Advancements, Applications and Theory in Downstream Processing." ...
    5-1-2013
  • Boosting Downstream Productivity
    The development of biopharmaceuticals, from initial lab work through production and final regulatory approval, is a complex process. Downstream processing steps can represent up to ...
    4-15-2013
  • Single-Use Bioreactor Roundup
    ... leachables are a minimum, but it can also be necessary to demonstrate that they are treated in the appropriate manner during the downstream processing step to limit any risks. Mr. ...
    4-15-2013
  • Hand-Held Homogenization Tool
    be released in as intact a form as possible within a reasonable time-frame without introducing additional chemicals to the system, which may interfere with downstream processing. ...
    4-15-2013
  • Media's Role in Cell Culture Success
    Related manufacturing issues include process robustness, reproducibility for both upstream and downstream processing, "quick-and-clean" processing, technical and regulatory ...
    4-1-2013
  • Scaling Up Peptide Drugs
    ... This may require adapting the chemistry used in synthesizing the peptides, Dr. Hay notes. He remarks on the continuous advances in peptide synthesis and downstream processing ...
    4-1-2013
  • Medicine: Getting Personal
    ... Automated processing of cells and cell-based products will be essential for achieving ... used in bioreactors. "I don't think we have the downstream technology yet," added Warren. ...
    3-15-2013
  • Molecular Characterization of CTCs
    of CTCs from blood samples in a format optimized for downstream molecular analysis. ... are collected (7-10 mL, BD EDTA tubes) and shipped to the processing site within 24 hours. ...
    3-15-2013
  • Nucleic Acid Sample Preparation in MDx
    ... at both the collection sites and for shipping to the processing and analysis centers. ... PAXgene is capable of preserving high-quality DNA for sensitive downstream applications, ...
    3-1-2013
  • Better Filtration Merges Innovation & Need
    ... viruses downstream are incapable of handling complex cell culture media. "Many cell culture media components are not filterable given the volumes and processing times ...
    3-1-2013
  • Growing the Biobased Economy
    ... the processing of food, manufacturing of chemicals, and assembly of clothing and consumer electronics. The industrial biotechnology industry needs to join with its downstream ...
    2-21-2013
  • Streamlining Media Design
    a quality-driven upstream process translates downstream to a high-quality final product. ... Designed with fewer processing steps and to specifically expand the range of nutritional ...
    2-1-2013
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    Journal Articles

  • Electrochemically Induced Crystallization as a Sustainable Method...
    Tahmineh Nasrollahnejad, Johan Urbanus, Joop H. ter Horst, Dirk Verdoes, Cornelis P.M. Roelands
    Industrial Biotechnology
    so-called base case produces a solid waste, while the second employs electrodialysis at the end of downstream processing to regenerate the waste salt and re-use the base and acid. ...
  • Was cDNA Sequences Modulate Transgene Expression of Was Promoter...
    Miguel G. Toscano, Karim Benabdellah, Pilar Muñoz, Cecilia Frecha, Marién Cobo, Francisco Martín
    Human Gene Therapy and Part B: Methods
    Insertion of Was cDNA sequences downstream of eGFP in these LVs had a negative effect on ... have demonstrated that the mechanism involves Was promoter regulation and RNA processing. ...
  • Reproducible High Yields of Recombinant Adeno-Associated Virus...
    Sylvain Cecchini, Tamas Virag, Robert M. Kotin
    Human Gene Therapy and Part B: Methods
    Using a variety of processing media, we developed a reliable and routine downstream procedure for rAAV production that is scalable from 0.02- to 200-liter cultures. To facilitate ...
  • Development and Evaluation of a Real-Time Fluorescent Polymerase...
    Gabriel Rensen, Wayne Smith, Juliana Ruzante, Mary Sawyer, Bennie Osburn, James Cullor
    Foodborne Pathogens and Disease
    We have developed a presample processing technique for extracting DNA from cattle feed ... PCR inhibitors and eluting the DNA from the FTA® card for downstream PCR analysis. ...

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