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  • Improving Proteomics Approaches
    ... in targeted proteomics at Laval University, described a high-throughput affinity purification-actually a profiling of the poly(ADP-ribose)-related response to DNA damage signaling. ...
    5-15-2013
  • Softening the Blow from FOLFOX Treatment
    ... many types of cancer, but which damaged the DNA in cancer cells, causing them to die. ... Side effects associated with treatment include sensory nerve damage, loss of white blood ...
    5-15-2013
  • Advertorial: Determining the Antioxidant Capacity of Beverages
    Cells that fail to compensate and neutralize heightened ROS levels die by apoptosis in order to avoid passing on ROS-caused DNA damage to daughter cells. Any dysfunction in the ...
    5-15-2013
  • Stem Cell Model of Neurodegenerative Disease Elucidates Potential...
    The researchers were able to model the characteristics of A-T in the laboratory, such as the cell's lack of ATM protein and inability to repair DNA damage. The model also allowed ...
    5-7-2013
  • Exposing the Exposome
    A key development is in epigenetics, a field that assumes a central position in the study of the exposome. In addition to the DNA damage model for carcinogenesis, recent years ...
    5-1-2013
  • Metabolomics Advances Reshape Dx Arena
    ... Antibodies are formulated into one of the six PTMScan Direct Reagents. The DNA Damage/Cell Cycle Reagent, for instance, targets 263 sites on 137 proteins, and the Apoptosis/...
    5-1-2013
  • Literature Review: Which Drug Combination Will Unlock Triple...
    TNBC cells from some patients appear to lack the ability to repair DNA damage efficiently, so platinum-containing drugs that cause DNA damage are being investigated in several ...
    4-25-2013
  • Direct DNA Sequencing Using Nanopore Sensors
    ... According to their research, cells lacking shelterin perceive their natural chromosome ends as sites of DNA damage. Her group is now working to determine the mechanism by which ...
    4-1-2013
  • Monoclonal Antibodies
    TCA specializes in designing and conducting assays for lead compounds and genotoxic screening based on DNA damage and repair as well as cancer cell behavior. XPF/ERCC1 forms a ...
    4-1-2013
  • Myriad to Use New HRD Test with PharmaMar's DNA-Damaging Drug
    According to Myriad, the HRD test is able to detect when a tumor has lost the ability to repair DNA damage and would therefore be more susceptible to the DNA-damaging classes of ...
    3-27-2013
  • Human Gene Connectome Mapped
    herpes virus that can cause significant brain damage in genetically susceptible children. ... gene, the researchers sequenced exomes-all DNA of the genome that is coding for ...
    3-20-2013
  • Bayer Taps ChromoTek's Drug Profiling Technology
    ChromoTek says that currently available Chromobodies trace cellular processes like cell cycle, apoptosis, DNA damage and repair, or allow cytoskeletal analysis. The Cell Cycle ...
    3-18-2013
  • Gene Expression Analysis Making Inroads
    pregnancy induce gene expression and DNA methylation changes in fetal tissues in sheep. ... proteins that affords them protection from the stresses that cause macromolecular damage. ...
    3-15-2013
  • Pre-Coated Well Plates
    TCA specializes in designing and conducting assays for lead compounds and genotoxic screening based on DNA damage and repair as well as cancer cell behavior. The 3D Culture ...
    3-15-2013
  • Cell Invasion Kit
    TCA specializes in designing and conducting assays for lead compounds and genotoxic screening based on DNA damage and repair as well as cancer cell behavior. The Cultrex® 3D cell ...
    3-1-2013
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    Journal Articles

  • Primary Human Hepatocytes from Metabolic-Disordered Children...
    Jeanette Bierwolf, Marc Lutgehetmann, Steffen Deichmann, Johannes Erbes, Tassilo Volz, Maura Dandri, Smadar Cohen, Bjoern Nashan, Joerg-Matthias Pollok, Joerg Matthias Pollok
    Tissue Engineering, Part A
    a marginal loss of hepatocytes was observed via measurement of DNA content per scaffold. ... 7. Low lactate dehydrogenase enzyme release demonstrated minor cellular membrane damage. ...
  • Expansion and Redifferentiation of Chondrocytes from Osteoarthritic...
    Nancy D. Hsieh-Bonassera, Iwen Wu, Jonathan K. Lin, Barbara L. Schumacher, Albert C. Chen, Koichi Masuda, William D. Bugbee, Robert L. Sah
    Tissue Engineering, Part A
    of constructs for treatment of joint-scale cartilage defects, damage, or osteoarthritis. ... Expansion was assessed as cell number estimated from DNA, growth rate, and day of maximal ...
  • NPR-C Protects Embryonic Stem Cells from Apoptosis by Regulating...
    Essam M. Abdelalim, Ikuo Tooyama
    Stem Cells and Development
    activation of p53 and Nanog suppression in the presence of DNA-damaging agents. Thus, NPR-C is required to control DNA damage-induced p53 levels to maintain ES cell self-renewal.
  • Ectopic Neurogenesis in the Forebrain Cholinergic System-Related...
    Xinhua Zhang, Guohua Jin, Wei Li, Linqing Zou, Jinhong Shi, Jianbing Qin, Meiling Tian, Haoming Li
    Stem Cells and Development
    cells were also positive for 5-bromo-2-deoxy-uridine, a marker of DNA synthesis. ... provides an additional mechanism for repair of cholinergic innervation following damage.

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