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Search Results - Compound Libraries
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  • HTRF Applications in New Drug Discovery
    ... Phenotypic Screens A scientist at the Novartis Institutes for Biomedical Research examines one of the company's compound libraries for potential new drug candidates to be used in ...
    7-1-2013
  • Live Content Imaging
    Up to six microplates (96-, 384-well) are housed within a single system, providing sufficient throughput for testing small compound or gene interference libraries. This approach is ...
    6-1-2013
  • Harnessing the Power of Kinase Inhibitors
    and full-length NIK in insect cells, and have translated this to a HEK293 cell-based system and performed proof-of-concept screens against compound libraries with both assays. ...
    5-8-2013
  • Light-Scattering Detectors
    Both can screen pharmaceutical compound libraries without sample preparation because they reduce interference from DMSO, and both complement the 6100 series of mass spectrometer ...
    2-1-2013
  • Lab Automation Sparks Creativity
    ... Paegel's team pursues a two-prong approach. First, the method for creating million-compound libraries uses prefabricated building blocks. The resulting compounds mimic natural ...
    1-1-2013
  • Genomic Analysis Drives Biomarker Discovery
    ... Compound libraries are screened against large panels of cell lines. The cell lines are randomly divided into two sets, a test set and a training set, and this strategy is used to ...
    1-1-2013
  • Tripping The Light Fantastic: New Reporter System
    ... This counter-intuitive result can greatly complicate the interpretation of compound ... However, HTS chemical libraries consist of structurally diverse small molecules that ...
    12-19-2012
  • Peptide-Seeking Platform Gets Boost from Tech Alliance
    MorphoSys will apply their respective technologies to establish lantipeptide libraries. ... peptides comprise an emerging compound class, which offers the potential to ...
    11-27-2012
  • Nurturing Protein Therapeutics to Next Level
    ... FGF-21 holds potential for treating type 2 diabetes, and the lead compound in this ... protein conjugation chemistry with Merck's antibody and small molecule libraries. ...
    11-15-2012
  • Improving HCA with Laser Scanning Imaging
    and early-phase drug discovery for cell target validation and multiparametric functional studies as well as for the screening of large compound libraries on key cellular targets. ...
    11-15-2012
  • China and India in Global Drug R&D Outsourcing
    ... For example, China has so far been the main place for global drug companies to source focused compound libraries, especially those derived from the natural products isolated and ...
    11-7-2012
  • Compound Family Found for Parkinson's Disease Therapy
    They claim the compound could provide the basis for a completely new approach to treating ... Interestingly, the investigators' initial screens of commercial libraries containing ...
    10-25-2012
  • Capitalizing on Down-to-Earth Discovery Tools
    ... microbial strains is the basis for its chemically diverse pure natural compound library. ... These libraries are continuously expanded and include more than 28,000 compounds based on ...
    10-15-2012
  • Automation Redefines Compound Management
    an evolution in compound-management tools. New technologies, as well as steady increases in available compounds, have made organizing and managing the libraries of chemicals, ...
    10-1-2012
  • Inhibitors That Put A Kink in Abl's Helix
    ... Due to intrinsic compound fluorescence, titration of 3-5 did not exceed 10 µM. (c) The ... assay design may uncover when screened against large libraries. | Mindy I. Davis, Ph.D.
    9-25-2012
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    Journal Articles

  • A Highly Specific Cell-Based High-Throughput Screening Assay...
    Hongxia Wang, Anisia J. Silva, Lynn Rasmussen, E. Lucile White, Jorge A. Benitez
    ASSAY and Drug Development Technologies
    this assay was 0.76 and its coefficient of variance 8 % for the positive control compound. ... The use of this assay to screen large chemical libraries could identify lead compounds to ...
  • Evaluation of a Range of Anti-Proliferative Assays for the Preclinical...
    Suja Elizabeth George, Rosaleen J. Anderson, Anne Cunningham, Michael Donaldson, Paul W. Groundwater
    ASSAY and Drug Development Technologies
    New agents for the treatment of psoriasis could be identified by high-throughput screening (HTS) of large compound libraries using keratinocyte proliferation models. Although ...
  • A Flexible Multiwell Format for Immunofluorescence Screening...
    Anne-Kathrin Scholz, Bert M. Klebl, Markus Morkel, Hans Lehrach, Andreas Dahl, Bodo M.H. Lange
    ASSAY and Drug Development Technologies
    high-throughput screening platforms that allow to analyze cellular traits on a genome-wide level or to identify small-molecule inhibitors (SMIs) from complex compound libraries. ...
  • In Pursuit of Synthetic Modulators for the Orphan Retina-Specific...
    Qiong Qin, Anna Knapinska, Nicoleta Dobri, Franck Madoux, Peter Chase, Peter Hodder, Konstantin Petrukhin
    Journal of Ocular Pharmacology and Therapeutics
    Conclusions A robust and reliable TR-FRET assay for small molecule NR2E3-specific modulators suitable for the analysis of million compound-strong HTS libraries was developed. A ...

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