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Search Results - Compound Libraries
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  • Harnessing the Power of Kinase Inhibitors
    and full-length NIK in insect cells, and have translated this to a HEK293 cell-based system and performed proof-of-concept screens against compound libraries with both assays. ...
    5-8-2013
  • Light-Scattering Detectors
    Both can screen pharmaceutical compound libraries without sample preparation because they reduce interference from DMSO, and both complement the 6100 series of mass spectrometer ...
    2-1-2013
  • Lab Automation Sparks Creativity
    ... Paegel's team pursues a two-prong approach. First, the method for creating million-compound libraries uses prefabricated building blocks. The resulting compounds mimic natural ...
    1-1-2013
  • Genomic Analysis Drives Biomarker Discovery
    ... Compound libraries are screened against large panels of cell lines. The cell lines are randomly divided into two sets, a test set and a training set, and this strategy is used to ...
    1-1-2013
  • Tripping The Light Fantastic: New Reporter System
    ... This counter-intuitive result can greatly complicate the interpretation of compound ... However, HTS chemical libraries consist of structurally diverse small molecules that ...
    12-19-2012
  • Peptide-Seeking Platform Gets Boost from Tech Alliance
    MorphoSys will apply their respective technologies to establish lantipeptide libraries. ... peptides comprise an emerging compound class, which offers the potential to ...
    11-27-2012
  • Nurturing Protein Therapeutics to Next Level
    ... FGF-21 holds potential for treating type 2 diabetes, and the lead compound in this ... protein conjugation chemistry with Merck's antibody and small molecule libraries. ...
    11-15-2012
  • Improving HCA with Laser Scanning Imaging
    and early-phase drug discovery for cell target validation and multiparametric functional studies as well as for the screening of large compound libraries on key cellular targets. ...
    11-15-2012
  • China and India in Global Drug R&D Outsourcing
    ... For example, China has so far been the main place for global drug companies to source focused compound libraries, especially those derived from the natural products isolated and ...
    11-7-2012
  • Compound Family Found for Parkinson's Disease Therapy
    They claim the compound could provide the basis for a completely new approach to treating ... Interestingly, the investigators' initial screens of commercial libraries containing ...
    10-25-2012
  • Capitalizing on Down-to-Earth Discovery Tools
    ... microbial strains is the basis for its chemically diverse pure natural compound library. ... These libraries are continuously expanded and include more than 28,000 compounds based on ...
    10-15-2012
  • Automation Redefines Compound Management
    an evolution in compound-management tools. New technologies, as well as steady increases in available compounds, have made organizing and managing the libraries of chemicals, ...
    10-1-2012
  • Inhibitors That Put A Kink in Abl's Helix
    ... Due to intrinsic compound fluorescence, titration of 3-5 did not exceed 10 µM. (c) The ... assay design may uncover when screened against large libraries. | Mindy I. Davis, Ph.D.
    9-25-2012
  • Evotec to Run NIH Small Molecule Repository
    compound-management capabilities into the U.S. east coast and also into Europe." The NIH Small Molecular Repository was established in 2004 as part of the Molecular Libraries ...
    9-19-2012
  • Building a Focused Library
    ... It can be used to build field templates that give a biological fingerprint for a protein target. This template can be used to screen compound collections or fragment libraries to ...
    9-15-2012
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    Journal Articles

  • Simultaneous Measurement of 10,000 Protein-Ligand Affinity Constants...
    James P. Landry, Yiyan Fei, Xiangdong Zhu
    ASSAY and Drug Development Technologies
    Molecular Library Screening Centers, making it a practical method in screening compound libraries for novel ligands and for system-wide affinity profiling of proteins, viruses, ...
  • Validating a Firefly Luciferase-Based High-Throughput Screening...
    Pulin Che, Long Cui, Olaf Kutsch, Liwang Cui, Qianjun Li
    ASSAY and Drug Development Technologies
    The LOPAC1280 small-compound library was used to validate this assay. Our results ... It is evident that this assay is suitable for large-scale screening of chemical libraries ...
  • Profiling Diverse Compounds by Flux- and Electrophysiology-Based...
    Beiyan Zou, Haibo Yu, Joseph J. Babcock, Pritam Chanda, Joel S. Bader, Owen B. McManus, Min Li
    ASSAY and Drug Development Technologies
    To provide a general basis for considering assays to profile large compound libraries for hERG activity, we have conducted parallel flux and electrophysiological analyses of 2,000 ...
  • The Use of High-Content Screening for the Discovery and Characterizati...
    Amy Barabasz, Briana Foley, James C. Otto, Anisa Scott, John Rice
    ASSAY and Drug Development Technologies
    expanded the ability of researchers to identify and quantify compound effects on a number of cellular events in a manner that allows for the rapid screening of chemical libraries. ...

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