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Search Results - Compound Libraries
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  • PMT-Based Hit Picking for HCA
    increase sample throughput, allowing libraries to be screened in a reasonable time frame. ... (i.e., toxicity) applications where the compound number screened is relatively small. ...
    10-1-2013
  • Novel 3D Cell Culture Systems
    ... In his presentation, Dr. Pardo described screens of large compound libraries using a bone metastatis assay or extra/intravasation assay, small-to-medium library screens with a 3D ...
    9-15-2013
  • Bayer, Broad on Five-Year Mission to Search for Novel Cancer...
    As part of the collaboration, the Broad Institute will share its oncogenomic expertise, and both parties will explore their compound libraries and use their screening platforms, as ...
    9-10-2013
  • Evotec and Jain Extend Research Collab in Skeletal Muscular Dystrophy
    Contract research organization (CRO) Evotec and the Jain Foundation are extending their research collaboration. The organizations indicate that they will screen compound libraries ...
    8-21-2013
  • Pfizer, Sanford-Burnham Team Up on Obesity, Diabetes Target Research
    to use CTI's resources, including select Pfizer compound libraries, proprietary screening methods, and antibody development technologies relevant to the investigators' work. ...
    8-13-2013
  • HTRF Applications in New Drug Discovery
    ... Phenotypic Screens A scientist at the Novartis Institutes for Biomedical Research examines one of the company's compound libraries for potential new drug candidates to be used in ...
    7-1-2013
  • Live Content Imaging
    Up to six microplates (96-, 384-well) are housed within a single system, providing sufficient throughput for testing small compound or gene interference libraries. This approach is ...
    6-1-2013
  • Harnessing the Power of Kinase Inhibitors
    and full-length NIK in insect cells, and have translated this to a HEK293 cell-based system and performed proof-of-concept screens against compound libraries with both assays. ...
    5-8-2013
  • Light-Scattering Detectors
    Both can screen pharmaceutical compound libraries without sample preparation because they reduce interference from DMSO, and both complement the 6100 series of mass spectrometer ...
    2-1-2013
  • Lab Automation Sparks Creativity
    ... Paegel's team pursues a two-prong approach. First, the method for creating million-compound libraries uses prefabricated building blocks. The resulting compounds mimic natural ...
    1-1-2013
  • Genomic Analysis Drives Biomarker Discovery
    ... Compound libraries are screened against large panels of cell lines. The cell lines are randomly divided into two sets, a test set and a training set, and this strategy is used to ...
    1-1-2013
  • Tripping The Light Fantastic: New Reporter System
    ... This counter-intuitive result can greatly complicate the interpretation of compound ... However, HTS chemical libraries consist of structurally diverse small molecules that ...
    12-19-2012
  • Peptide-Seeking Platform Gets Boost from Tech Alliance
    MorphoSys will apply their respective technologies to establish lantipeptide libraries. ... peptides comprise an emerging compound class, which offers the potential to ...
    11-27-2012
  • Nurturing Protein Therapeutics to Next Level
    ... FGF-21 holds potential for treating type 2 diabetes, and the lead compound in this ... protein conjugation chemistry with Merck's antibody and small molecule libraries. ...
    11-15-2012
  • Improving HCA with Laser Scanning Imaging
    and early-phase drug discovery for cell target validation and multiparametric functional studies as well as for the screening of large compound libraries on key cellular targets. ...
    11-15-2012
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    Journal Articles

  • Micro Parallel Liquid Chromatography: Enabling Technology for...
    Anthony V. Lemmo, Steve Hobbs, Paren Patel
    ASSAY and Drug Development Technologies
    ASSAY and Drug Development Technologies Since the introduction of combinatorial chemistry, compound libraries have undergone a significant increase in size and diversity. The ...
  • Evaluation of an Orthogonal Pooling Strategy for Rapid High-Throughput...
    Nuzhat Motlekar, Scott L. Diamond, Andrew D. Napper
    ASSAY and Drug Development Technologies
    Abstract: Orthogonal pooling was evaluated as a strategy for the rapid screening of multiple cysteine and serine proteases against large compound libraries. To validate the method ...
  • A High Throughput Screening Assay to Screen for CYP2E1 Metabolism...
    Bryan D. Marks, Ronald W. Smith, Heidi A. Braun, Tony A. Goossens, Marie Christenson, Mary S. Ozers, Connie S. Lebakken, Olga V. Trubetskoy
    ASSAY and Drug Development Technologies
    ASSAY and Drug Development Technologies Large-scale screening of multiple compound libraries and combinatorial libraries for pharmacological activity is one of the novel approaches ...
  • A Flexible Multiwell Format for Immunofluorescence Screening...
    Anne-Kathrin Scholz, Bert M. Klebl, Markus Morkel, Hans Lehrach, Andreas Dahl, Bodo M.H. Lange
    ASSAY and Drug Development Technologies
    high-throughput screening platforms that allow to analyze cellular traits on a genome-wide level or to identify small-molecule inhibitors (SMIs) from complex compound libraries. ...

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