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  • Improving Proteomics Approaches
    ... Binding is determined through in vitro assays and cell-based assays. "We do a lot of co-crystallizations as well," Dr. Gräslund said. Most of the proteins employed in this work ...
    5-15-2013
  • Mass Spec Provides Peek into PTMs
    The detection of O-GlcNAc modification can be done by classical biochemical assays (e.g., ... Dr. Kelleher has articulated a new "cell-based" version of the Human Proteome Project, ...
    5-15-2013
  • Harnessing the Power of Kinase Inhibitors
    However, cell-based assays do have their disadvantages, primarily that most hits often exhibit cytotoxicity. His research team began by performing a dual transfection assay of ...
    5-8-2013
  • The Tumor Microenvironment as a Drug Target: Chasing Slippery...
    ... the cells that express FAP with antibody-conjugated toxin and cell-based immunotherapies." ... prodrug in vitro in cell proliferation assays and assessed its effects on intracellular ...
    5-1-2013
  • Media's Role in Cell Culture Success
    ... like mycoplasma and viruses. Want more on cell culture? Be sure to check out the Expert Tips " Best Practices to Optimize Your Cell-Based Assays ". | Angelo DePalma, Ph.D.
    4-1-2013
  • Predicting Drug Toxicity in Humans
    ... children and in adults. "We do all the assays involving a variety of endpoints ... Dr. Compagnone's team has developed a cell-based high-throughput screening (HTS) ...
    4-1-2013
  • Advertorial: United States Pharmacopeial Convention
    in a wide variety of areas, including naturally derived biologics; recombinant therapeutics; vaccines; bioassays and cell-based assays; and ancillary and process materials. ...
    4-1-2013
  • Best Practices to Optimize Your Cell-Based Assays
    Take your assays to the edge with these tips. New techniques help researchers reduce edge effects on cell-based assays to increase assay performance and improve long-term ...
    3-28-2013
  • Medicine: Getting Personal
    ... ISTO Technologies, an orthobiologics company, has two cell-based allogeneic products in .../leachable data is already available and otherwise performing the appropriate assays. ...
    3-15-2013
  • Meeting the Bioassay Challenge
    ... "Good, specialized statistical input is crucial for design and analyses of cell-based potency assays and is very helpful when using DOE to help guide assay development," comments ...
    3-15-2013
  • Organovo and ZenBio Form 3D Bioprinting Partnership
    "This is especially true for potency assays, which are a regulatory requirement for ... and ZenBio is a provider of advanced cell-based solutions and services. Organovo and ...
    2-20-2013
  • Cell Migration Well Plates
    & tools company that currently offers a disruptive solution that brings robustness, sensitivity and powerful quantification to cell-based assays and High Content Screening (HCS). ...
    2-15-2013
  • High-Content Screening Broadens Its Scope
    ... subjected to statistical image data analysis. "These algorithms for analysis of cell-based assays allow us to identify which drugs are safe or toxic, and potentially predict ...
    2-1-2013
  • Tying Up Loose Ends in Cell-Line Development
    ... necrosis, differentiation, and others for cell-based assays. "In my opinion one of the main limitations of the technology is efficiency variations for various cell types," Dr. ...
    2-1-2013
  • Overcoming Roadblocks in Cell-Based Assay Research
    Miniaturized Format Was Designed to Integrate into Existing Workflows Cell-based assays have become fundamental and irreplaceable tools in drug discovery and life science, ...
    2-1-2013
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    Journal Articles

  • Hierarchically Designed Agarose and Poly(Ethylene Glycol) Interpenetra...
    Brandon J. DeKosky, Nathan H. Dormer, Ganesh C. Ingavle, Christopher H. Roatch, Joseph Lomakin, Michael S. Detamore, Stevin H. Gehrke
    Tissue Engineering, Part C: Methods
    cell viability assays demonstrated that cells survived the IPN encapsulation process. ... This method can be applied to fabricate a broad variety of cell-based IPNs by varying ...
  • A Comparison of Human Smooth Muscle and Mesenchymal Stem Cells...
    Corin Williams, Angela W. Xie, Sirisha Emani, Masayuki Yamato, Teruo Okano, Sitaram M. Emani, Joyce Y. Wong
    Tissue Engineering, Part A
    Assays for calcification and alkaline phosphatase activity revealed that the osteogenic ... Although hMSCs are promising for cell-based TEVPs in their ability to form robust tissue ...
  • In vitro Adipogenic Differentiation of Preadipocytes Varies with...
    D. Heath Stacey, Summer E. Hanson, Garet Lahvis, Karol A. Gutowski, Kristyn S. Masters
    Tissue Engineering, Part A
    Despite the rapidly growing body of work on stem cell-based adipose tissue engineering, ... Assays for adipogenic markers (leptin, adiponectin, and glycerol) and Oil Red O staining ...
  • Targeted Delivery of Murine IFN- γ Using a Recombinant Fowlpox...
    Hasan Zeytin, Eva Reali, David A. Zaharoff, Connie J. Rogers, Jeffrey Schlom, John W. Greiner
    Journal of Interferon & Cytokine Research
    The cell-based vaccine was completely ineffective if mice were vaccinated with MC38 cells ... Flow cytometric analyses coupled with functional assays confirmed the sustained presence ...

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