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  • Improving Proteomics Approaches
    ... function. "One purpose is to concentrate cell-signaling molecules," explained Susan Daniel, Ph.D., assistant professor of chemical and biological engineering at Cornell University. ...
    5-15-2013
  • Companion Diagnostics: 52 Pick-Up
    ... Drug and specific indication undisclosed. Financial terms not disclosed. Roche (Ventana Medical Systems), Pfizer, and Cell Signaling Technology (CST) Agreement announced January 9, ...
    5-9-2013
  • The Tumor Microenvironment as a Drug Target, Part II
    ... RhoB and AKT Signaling Investigators at Beth Israel Deaconess Medical Center and Harvard Medical School observed that the distinct characteristics of stromal cell signaling ...
    5-7-2013
  • Migraines Linked to Gene Mutation
    of migraine in humans, in a mouse model of migraine and in cell culture in the laboratory. ... of mutant mice showed increased calcium signaling compared with astrocytes from the brains ...
    5-2-2013
  • Two Proteins Found to Block Cancer Metastasis
    Mittal, Ph.D., an associate professor of cell and developmental biology in ... tumors also send out signaling molecules that establish what is known ...
    5-1-2013
  • Metabolomics Advances Reshape Dx Arena
    ... said Matthew P. Stokes, Ph.D., scientist III, proteomics service group, Cell Signaling Technology. "Motif antibodies and other generalized enrichment strategies produce ...
    5-1-2013
  • Biologically Relevant Laminins
    ... The natural biological signaling pathways that are activated in hPSCs through this mechanism demonstrates that no artificial inhibitors such as ROCK or LIF are needed for high cell ...
    5-1-2013
  • Exploring GPCRs as Therapeutic Targets
    ... largely in vitro or using reduced cell culture preparations, to in vivo effects ... mechanisms of GPCR trafficking and GPCR signaling, according to Dr. von Zastrow. "The idea ...
    4-15-2013
  • Antibody Microarray Kit
    This can provide researchers with a proteomics tool to study changes in cell-signaling proteins that occur in response to treatments, drugs, toxins, pathological, and other ...
    4-15-2013
  • Knockout Cell Lines for Cancer Research
    CanCELL cell lines are generated using TALEN(tm) technology and offer opportunities to study signaling pathways and gene function, as well as supporting development of functional ...
    4-15-2013
  • Autism Mutations and Marijuana Affect the Same Brain Pathway
    was reported online yesterday in the Cell Press journal Neuron. The paper is titled "Autism-Associated Neuroligin-3 Mutations Commonly Disrupt Tonic Endocannabinoid Signaling". ...
    4-12-2013
  • Expanding Cell Analysis in Cancer Research with Imaging Flow...
    Cancer cell biologists Cancer drug developers Membrane protein biochemists Cell signaling scientists Stem cell biologists | Deputy Head of Facility Andrew Filby, Ph.D. | ...
    4-10-2013
  • Women and Smoking
    ... loss of estrogen-dependent lung cancer cell growth. Nonetheless, the authors said, estrogen caused rapid activation of cAMP- and MAPK-signaling pathways in lung cancer cells, ...
    4-3-2013
  • ArQule Regains Rights to AKT Inhibitor from Daiichi Sankyo
    The AKT signaling pathway plays a role in regulating cell growth, survival, migration, and angiogenesis, activities that are often disrupted in cancer. ArQule's lead product is ...
    4-1-2013
  • How Vitamin E Might Prevent Cancer
    ... The study will appear in the March 19, 2013, issue of the journal Science Signaling. A form of vitamin E inhibits the activation of an enzyme that is essential for cancer cell ...
    3-15-2013
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    Journal Articles

  • Three-Dimensional Loading Model for Periodontal Ligament Regeneration...
    Agnes D. Berendsen, Theo H. Smit, X. Frank Walboomers, Vincent Everts, John A. Jansen, Antonius L.J.J. Bronckers
    Tissue Engineering, Part C: Methods
    Cell responses were recorded by measuring expression of three sets of genes: (i) cyclooxygenase 1 and 2 (COX-1, COX-2) producing prostaglandins (signaling molecules); (ii) Runx2, a ...
  • Stereolithographic Bone Scaffold Design Parameters: Osteogenic...
    Kyobum Kim, Andrew Yeatts, David Dean, John P. Fisher
    Tissue Engineering, Part B: Reviews
    Scaffold porosity and pore size affect osteogenic cell signaling and ultimately in vivo bone tissue growth. Alternatively, scaffold interconnectivity has a great influence on in ...
  • Coculture Strategies in Bone Tissue Engineering: The Impact of...
    Sathyanarayana Janardhanan, Martha O. Wang, John P. Fisher
    Tissue Engineering, Part B: Reviews
    of Culture Conditions on Pluripotent Stem Cell Populations Tissue Engineering, Part B: ... of bone tissue, and particularly the critical intercellular signaling pathways. ...
  • Three-Dimensional In Vitro Tri-Culture Platform to Investigate...
    Taymour M. Hammoudi, Catherine A. Rivet, Melissa L. Kemp, Hang Lu, Johnna S. Temenoff
    Tissue Engineering, Part A
    We developed an enabling platform to isolate and study effects of signaling interactions between tissue-scale, laminated hydrogel modules of multiple cell types in tandem. We ...

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