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Search Results - CNS Diseases
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  • Harnessing the Power of Kinase Inhibitors
    ... the blood-brain barrier if targeting the CNS, and for any application, a molecular ... which is a target for autoinflammatory diseases like asthma, IBD, and rheumatoid ...
    5-8-2013
  • Merck Launches Up To $430M Diabetes Collaboration with Abide
    They include regulating CNS signaling, digestion, metabolism, inflammation, blood ... patients with diabetes and metabolic diseases," Alan Ezekowitz, D.Phil., co-founder, ...
    5-2-2013
  • Predicting Drug Toxicity in Humans
    ... are central to drug development as targets in CNS diseases, cancer, and metabolic diseases and as one of the main off-target sites causing undesirable side effects and toxicity. ...
    4-1-2013
  • Edison Will Receive Up To $525M in Mitochondrial and CNS Disease...
    to advance EPI-743 in other Phase II trials for rare pediatric diseases with shared mitochondrial mechanisms. Edison Will Receive Up To $525M in Mitochondrial and CNS Disease Deal
    3-28-2013
  • Merck Sells COMT Inhibitor Rights to Cerecor
    But COMT inhibition is said to have broad potential applicability in other CNS diseases, such as addictive behaviors and schizophrenia, by specifically increasing dopamine levels ...
    3-20-2013
  • Takeda Expands Envoy-Scripps Collaboration
    for new drug targets for a variety of diseases. Envoy was acquired by Takeda Pharmaceuticals last November to obtain access to Envoy's CNS drug pipeline. "We originally came to ...
    3-13-2013
  • New CNS Compound Library Goal of Multi-Foundation Collab
    Hospital, the CCSI will share emerging compounds with the potential to treat diseases of the CNS among academic CNS drug discovery centers with the goal of maximizing their ...
    2-28-2013
  • Proteologics, Newcastle Innovation Aim to Help Others Breathe...
    for many types of cancer, metabolic disease, viral infections, and CNS-related disorders. ... therapeutics for respiratory and other diseases based on the target Midline-1, an E3 ...
    2-20-2013
  • Notorious Alzheimer's Protein Could Be Used to Grow New Cells...
    study found that central nervous system (CNS) neurons from rats cultured in apoE4 grew ... the body that might then be implanted to treat people with neurodegenerative diseases. ...
    1-30-2013
  • Genentech Buys Afraxis Compound Rights for Up to $187.5M
    Afraxis discovers and develops drugs for diseases of the central nervous system including ... In licensing the Afraxis compounds, Genentech aims to boost the CNS-drug portion of its ...
    1-29-2013
  • Drug Repurposing Rekindles Promise
    ... Should these findings in animals translate into effects on human diseases, it could ... for some of the most intractable CNS disorders, CVD, metabolic disorders, and cancer. ...
    1-25-2013
  • GPCRs Targeted in Heptares/Cubist Collab
    Heptares' adenosine A 2A receptor antagonist candidate for the treatment of CNS disorders. ... broad range of biological processes and diseases. GPCRs Targeted in Heptares/Cubist ...
    1-7-2013
  • BioMarin Buys Zacharon for $10M Up Front
    and inhibition of ganglioside synthesis for diseases such as Tay Sachs and Sandhoff. ... the exciting prospect of treating both the CNS and peripheral manifestations of MPS III, ...
    1-7-2013
  • The New Economics of Orphan Diseases
    ... In contrast, acute myeloid leukemia and Hodgkin lymphoma markets are likely to experience much higher growth, according to GBI analysts. CNS Diseases Huntington's disease, ...
    1-1-2013
  • Epigenetics Conjugates
    mechanisms and how they relate to multiple therapeutic areas and diseases such as metabolic, CNS, and immune system disorders. The toolbox works in combination with other ...
    11-15-2012
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    Journal Articles

  • Long-Term Culture of Mouse Embryonic Stem Cell-Derived Adherent...
    Mirian A.F. Hayashi, Juliano R. Guerreiro, Antonio C. Cassola, Nelson F. Lizier, Alexandre Kerkis, Antonio C.M. Camargo, Irina Kerkis
    Tissue Engineering, Part C: Methods
    which is a characteristic feature of the functional central nervous system (CNS) neurons. ... model for studying neurological diseases associated with neuronal differentiation ...
  • Neurogenesis in Diseases of the Central Nervous System
    Wendy Phillips, Andrew W. Michell, Roger A. Barker
    Stem Cells and Development
    Neurogenesis in Diseases of the Central Nervous System Stem Cells and Development Neurogenesis is altered in ageing, and diseases of the central nervous system (CNS) such as ...
  • Human Mesenchymal Stem Cells Express Neural Genes, Suggesting...
    Netta R. Blondheim, Yossef S. Levy, Tali Ben-Zur, Alex Burshtein, Tirza Cherlow, Inna Kan, Ran Barzilai, Merav Bahat-Stromza, Yael Barhum, Shlomo Bulvik, Eldad Melamed, Daniel Offen
    Stem Cells and Development
    into the central nervous system (CNS) differentiate to a variety of functional ... human MSCs are promising candidates for cell-based therapy of neurodegenerative diseases.
  • 4-Chloro-3-Hydroxyanthranilate Reduces Local Quinolinic Acid...
    Jennifer R. Yates, Melvyn P. Heyes, Andrew R. Blight
    Journal of Neurotrauma
    Inflammatory processes within the central nervous system (CNS) contribute significantly to the pathogenesis of a broad range of neurologic diseases, including spinal cord injury ...

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