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Search Results - BRAF
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  • NCI Re-Ups BioMarker Strategies' SBIR Award for Melanoma CDx
    test validation in clinical samples. "Targeted therapies now exist, including the BRAF inhibitor vemurafenib, that can help melanoma patients keep their cancer in check," ...
    9-25-2013
  • Cutting Melanoma Off at the Pass
    to a combination of BRAF and MEK inhibitors. They found that resistant melanomas acquired a mutation in the MEK2 gene and multiple copies of the mutant BRAF oncogene, ...
    9-20-2013
  • Companion Diagnostics: Improving Development Success and Patient...
    Tafinlar® (dabrafenib), a BRAF inhibitor that targets a certain mutation in the BRAF gene, together with a companion diagnostic identifying patients having that specific mutation. ...
    8-5-2013
  • Ovarian Cancer Treatment Milestone Earns Array BioPharma $5M
    Novartis recently detailed plans to initiate Phase III trials of MEK162 in both NRAS- and BRAF-mutant melanoma. All three trials will be conducted as part of the Novartis/Array ...
    7-2-2013
  • Assay Development Driving Personalized Medicine
    ... Merck. "The most notable success stories recently are the identification of BRAF mutations in melanoma for vemurafenib and the identification of ALK translocations for crizotinib." ...
    7-1-2013
  • GSK Hits Trifecta with Melanoma Drug, Dx Approvals
    or unresectable melanoma in adult patients with the BRAF V600E mutation, which accounts for about 85% of all BRAF V600 mutations in metastatic melanoma, according to a study ...
    5-30-2013
  • Companion Diagnostics: 52 Pick-Up
    ... COBAS 4800 BRAF V600 Mutation Test Sponsor/Developer: Roche Molecular Systems Intended Use/Indications for Use: Intended for the qualitative detection of the BRAF V600E mutation in ...
    5-9-2013
  • NGS Sample Prep Library Kit
    Swift Biosciences opened its doors in February 2010 and launched the first retail product in its myT(tm) Primers platform-myT(tm) BRAF-for detection of BRAF mutations in February ...
    4-15-2013
  • Development and Evolution of PCR
    ... In some cases, the assay is co-developed with the drug and is known as a companion diagnostic (e.g., Zelboraf, which targets melanoma tumors harboring the BRAF V600E mutation). The ...
    4-1-2013
  • Advertorial: Swift Biosciences
    ... Swift has developed myT Primers for the common mutations in BRAF and KRAS genes to ... In 2012, Swift launched two Research Use Only (RUO) myT Primer sets for BRAF V600E/K ...
    4-1-2013
  • Personalized Medicine: Translation of Concepts
    Examples include Her-2/neu (Trastuzumab/Lapatinib), KRAS (Cetuximab/Panitumomab), BRAF (Vemurafenib), and CCR5 (Maraviroc). We Lack Model Systems to Predict Drug Response In our ...
    3-19-2013
  • Unlocking Biomarkers' Full Potential
    ... For example, EGFR measures the level of receptor expression; Braf and Kras markers measure the presence of the mutation and translocation in the ALK gene measures gene knockout. It ...
    2-1-2013
  • Tumor Bank Lends Expertise to Drug Firms
    ... Among the newest is a clinically validated BRAF test that detects the V600E mutation found ... The FDA has approved drugs that target BRAF mutations, such as Roche's recently released ...
    2-1-2013
  • A "Very Good Year" for Roche
    Zelboraf® for BRAF V600 mutation-positive metastatic melanoma rang up its first sales in ... Europe and the United States as a result of higher-than-expected BRAF testing rates. ...
    1-30-2013
  • The New Economics of Orphan Diseases
    ... a growing number of orphan indications that are actually sub-populations of larger nonrare diseases, such as BRAF mutated melanoma and ALK-translocated NSCLC," Dr. Meekings says. ...
    1-1-2013
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    Journal Articles

  • Reflex BRAF Testing in Thyroid Fine-Needle Aspiration Biopsy...
    Adebowale J. Adeniran, Constantine Theoharis, Pei Hui, Manju L. Prasad, Lynwood Hammers, Tobias Carling, Robert Udelsman, David C. Chhieng
    Thyroid
    Reflex BRAF Testing in Thyroid Fine-Needle Aspiration Biopsy with Equivocal and Positive Interpretation: A Prospective Study Thyroid Background: The BRAF V600E mutation has been ...
  • BRAF Mutations are Uncommon in Papillary Thyroid Cancer of Young...
    Karen Penko, Jeffrey Livezey, Cydney Fenton, Aneeta Patel, Diarmuid Nicholson, Michael Flora, Kevin Oakley, R. Michael Tuttle, Gary Francis
    Thyroid
    BRAF Mutations are Uncommon in Papillary Thyroid Cancer of Young Patients Thyroid ... reports describe a high incidence of BRAF T1796A transversion in adult PTC. However, ...
  • BRAF, A TOOL IN THE DECISION TO PERFORM ELECTIVE NECK DISSECTION...
    Simone Elisa Dutenhefner, Suemi Marui, Andre Bandiera Santos, Erika Urbano Lima, Milton Inoue, Jose de Souza Brandao Neto, Christina Shiang, Julia Fukushima, Claudio Roberto Cernea, Celso Friguglietti
    Thyroid
    BRAF, A TOOL IN THE DECISION TO PERFORM ELECTIVE NECK DISSECTION? Thyroid Background: Some studies have demonstrated a correlation between the BRAF mutation and aggressive ...
  • BRAF Status of Follicular Variant of Papillary Thyroid Carcinoma...
    Agnese Proietti, Riccardo Giannini, Clara Ugolini, Mario Miccoli, Gabriella Fontanini, Giancarlo Di Coscio, Rossana Romani, Piero Berti, Paolo Miccoli, Fulvio Basolo
    Thyroid
    BRAF Status of Follicular Variant of Papillary Thyroid Carcinoma and its Relationship to ... To attempt to clarify this diagnostic problem, we analyzed the BRAF status of thyroid ...

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