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Search Results - Animal Models
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  • Seasoned Drugs Offer Therapeutic Gold Mine
    ... two drug candidates (BVA-101 and BVA-201) that they then validated as effective in animal models of MS. "COSS was thus able to help redefine the potential mechanism of the disease, ...
    5-15-2013
  • In Vivo Imaging Agent
    GFR-Vivo 680, in combination with fluorescence molecular tomography imaging, can provide a noninvasive approach to generate consistent GFR measurements in animal models of kidney ...
    5-15-2013
  • Highlights from AACR
    ... fluorescent agent for obtaining noninvasive measurements of the glomerular filtration rate in vivo to assess animal models of kidney disease, dysfunction, and drug toxicity. ...
    5-15-2013
  • Harnessing the Power of Kinase Inhibitors
    ... Chantry also notes that the alternative global approaches of molecular-driven target discovery, such as using an shRNA knockdown approach or systematic knockouts in animal models, ...
    5-8-2013
  • Metabolomics Advances Reshape Dx Arena
    ... Eugenia Trushina, Ph.D., associate consultant, Mayo Clinic. "Some assessments, such as mitochondrial trafficking and distribution in neurons, could only be done in animal models. ...
    5-1-2013
  • Human iPSC-Derived Hepatocytes
    and animal donors that can be studied as intact liver slices or though the dissociation and isolation of primary hepatocytes. Limitations of these cell and tissue models ...
    5-1-2013
  • Hormone Holds Promise for Replacing Insulin Injections
    That expression correlated with beta cell proliferation in other mouse models of insulin ... it, too. "We were just wondering what happens when an animal doesn't have enough insulin. ...
    4-26-2013
  • miRNA: The Key to Losing Those Love Handles?
    Scientists at the University of Bonn working with Alexander Pfeifer, Ph.D., director of the Institute for Pharmacology and Toxicology, have spent years using animal models to ...
    4-24-2013
  • Biosimilars: 10 Drugs to Watch
    ... was awarded U.S. Patent No. 8,404,252. The iBioModulator has been shown in animal models to increase the strength and extend the duration of immune response to a vaccine antigen. ...
    4-22-2013
  • Literature Review: Bacteria Reprogram Host Cells in Order to...
    bacterium causing leprosy, Mycobacterium leprae , has been next to impossible to study because of extreme difficulties associated with its culturing and the lack of animal models. ...
    4-18-2013
  • Performing "Informative Clinical Trials" in Mice
    Patient-derived tumor xenografts: better than cancer cell lines for preclinical testing in animal models? The high costs and failure rates of cancer drug development underscore the ...
    4-17-2013
  • ARMGO Gets $1M for Muscular Dystrophy Drug
    According to the company, Rycals have been shown in animal models of muscle disease to repair RyR-mediated calcium leak and thereby improve specific muscle force and exercise ...
    4-17-2013
  • Exploring GPCRs as Therapeutic Targets
    ... Int vitro models, such as inducible pluripotent stem cells, can give relevant information in a disease context, which can in turn "inform translational animal models that may more ...
    4-15-2013
  • Advances in RNAi Tools and Technologies
    for in vivo applications based on the parental Silencer Select platform, have proven to be highly stable when injected into the bloodstream of animal models, he continues. ...
    4-15-2013
  • Single-Use Bioreactor Roundup
    ... Marner: One challenge for single-use implementation is translation of these models for gas ... sufficent power in culture for animal and, in the case of ambr250, microbial cultures. ...
    4-15-2013
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    Journal Articles

  • Treatment of Obesity Using GH
    Thue Johansen, Kjell Malmlöf
    Metabolic Syndrome and Related Disorders
    The mechanisms underlying the response to GH administration have also been investigated in animal models of human obesity. A literature search yielded 19 randomized ...
  • Stem Cells in Dental Pulp of Deciduous Teeth
    Irina Kerkis, Arnold I. Caplan
    Tissue Engineering, Part B: Reviews
    their developmental potential, immunological compatibility, tissue engineering, and transplantation use in studies in animal models are also the focus of the current report. ...
  • Cell Sources for Bone Tissue Engineering: Insights from Basic...
    Céline Colnot
    Tissue Engineering, Part B: Reviews
    This review provides an overview of animal models used to test the efficacy of cell-based approaches. We examine the mechanisms of endogenous cell recruitment during bone repair ...
  • Direct Gene Therapy for Bone Regeneration: Gene Delivery, Animal...
    Gadi Pelled, Ayelet Ben-Arav, Colleen Hock, David G. Reynolds, Cemal Yazici, Yoram Zilberman, Zulma Gazit, Hani Awad, Dan Gazit, Edward M. Schwarz
    Tissue Engineering, Part B: Reviews
    Direct Gene Therapy for Bone Regeneration: Gene Delivery, Animal Models, and Outcome Measures Tissue Engineering, Part B: Reviews While various problems with bone healing remain, ...

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