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  • Pluristem Wins $3.3M Israeli Grant to Advance Pipeline
    Pluristem's pre-clinical animal models had previously shown PLX cells were potentially effective in nerve pain and muscle damage when administered locally, and in inflammatory ...
    8-6-2013
  • MultiCell, Genisphere to Target Liver Cancer with Nanoparticles
    including being safe enough to allow parenteral administration by infusion or topical administration, will be developed and tested in animal models of hepatocellular carcinoma. ...
    8-6-2013
  • Improving Preclinical Research
    ... Kimmelman and his colleagues note in their paper, despite even the best intentions, "preclinical researchers might use treatments, animal models, or outcome assessments that are a ...
    7-29-2013
  • Transition Scores Rights to Develop Lilly Osteoarthritis Pain...
    class have shown target engagement in the joint space and efficacy in multiple animal models of joint pain," said Tony Cruz, Ph.D., chairman and CEO of Transition. "We look ...
    7-24-2013
  • Pfizer Licenses Phase II TB Antibiotic Rights to Sequella
    activity against Mycobacterium tuberculosis in preclinical lab studies and animal models of TB. "We are delighted to bring in a second clinical-phase TB asset that may be ...
    7-17-2013
  • SK Biopharmaceuticals, AriBio Team Up to Develop Glaucoma Candidate
    SK Biopharmaceuticals-a pharma firm spun out in April 2011 from SK Holdings, the third-largest conglomerate in South Korea-has been evaluating SKL-G's potential in animal models ...
    7-5-2013
  • Closer-to-Real 3D Cell Culture Advances
    New in vitro technologies have a real chance of replacing animal models for drug testing, yet some challenges remain. As the 360 government-owned chimpanzees officially retired on ...
    7-3-2013
  • Gene Editing to Treat Genetic Diseases, Part II
    ... Dr. Gersbach says his group is now conducting further tests of this new approach in animal models of the disease, as well as exploring delivery of the gene correcting enzymes ...
    6-20-2013
  • Macrocycles Shake Up Small Molecules
    ... First, the oral bioavailability of these compounds was significantly increased as demonstrated in our studies using animal models. Our vision is to design a drug that is not only ...
    6-15-2013
  • More Than a Messenger: A New Class of Drugs-mRNA-Based Therapeutics
    ... vaccination for infectious diseases, and a recent proof-of-concept study in animal models for influenza was published in Nature Biotechnology. 7 Other Therapeutic ...
    6-14-2013
  • Aphios, VivaCell to Develop Cannabinoid-Based Drugs for MS, CNS...
    "In vivo experiments have shown that they cross the blood-brain barrier and inhibit neuroinflammation in well-defined animal models of multiple sclerosis and Huntington's disease." ...
    6-12-2013
  • Seeking New Tools Against Alzheimer's
    ... NPT002 mediated clearance of misfolded protein deposits-including amyloid-beta, tau, and alpha-synuclein-in multiple animal models, resulting in cognitive and behavioral ...
    6-7-2013
  • Strategies to Optimize Cell Culture
    the risk is often done, particularly the migration away from materials of animal origin. ... produce the material," says Goetschalckx. "We've developed qualified small-scale models. ...
    6-1-2013
  • Seasoned Drugs Offer Therapeutic Gold Mine
    ... two drug candidates (BVA-101 and BVA-201) that they then validated as effective in animal models of MS. "COSS was thus able to help redefine the potential mechanism of the disease, ...
    5-15-2013
  • In Vivo Imaging Agent
    GFR-Vivo 680, in combination with fluorescence molecular tomography imaging, can provide a noninvasive approach to generate consistent GFR measurements in animal models of kidney ...
    5-15-2013
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    Journal Articles

  • Critical Need for Appropriate Mucosal Sample Collection to determine...
    Leslie Marshall, James Cummins, Hans Spiegel, Jim Turpin, Fulvia Veronese, Angela Kashuba
    AIDS Research and Human Retroviruses
    Critical Need for Appropriate Mucosal Sample Collection to determine Relational Animal Pharmacokinetic-Pharmacodynamic Models in HIV Prevention AIDS Research and Human Retroviruses
  • Mechanisms and Drug Therapy of Pulmonary Hypertension at High...
    Urs Scherrer, Yves Allemann, Emrush Rexhaj, Stefano F. Rimoldi, Claudio Sartori
    High Altitude Medicine & Biology
    In animal models of fetal programming of hypoxic pulmonary hypertension epigenetic mechanism play a role and targeting of these mechanisms with drugs lowers pulmonary artery ...
  • A Canadian Application of One Health: Integration of Salmonella...
    Elizabeth Jane Parmley, Katarina Pintar, Shannon Majowicz, Brent Avery, Angela Cook, Cassandra Jokinen, Vic Gannon, David R. Lapen, Ed Topp, Tom A. Edge, Matthew Gilmour, Frank Pollari, Richard Reid-Smith, Rebecca Irwin
    Foodborne Pathogens and Disease
    in the different components under surveillance (animal, food, environment and human). ... Taken together, surveillance models that encompass different scales can leverage ...
  • Understanding roles of porcine small intestinal submucosa (SIS...
    Hsueh-Kung Lin, Shirley Yezdi Godiwalla, Blake W Palmer, Dominic Frimberger, Qing Yang, Sundararajan V Madihally, Kar-Ming Fung, Bradley Kropp
    Tissue Engineering, Part B: Reviews
    bioscaffold is best known to encourage bladder regeneration without ex vivo cell seeding prior to implantation in various experimental and pre-clinical animal models. ...

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