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  • Over 3,500 RNA Editing Sites Declared Bona Fide
    ... In humans, perturbed RNA editing has been strongly implicated in the diseases ALS and Acardi-Gutieres disease. Sanger sequencing-based analysis has been used to stringently ...
    9-30-2013
  • Imposter Amino Acid Mimics Serine, Kinks Neuroproteins, Prompts...
    The scientists speculate that BMAA, which has been detected in the brain tissues of ALS ... These diseases include ALS, Alzheimer's disease, and Parkinson's disease. To date, ...
    9-26-2013
  • Harvard Stem Cell Institute, Evotec Team Up to Take on ALS
    amyotrophic lateral sclerosis (ALS). The collaboration, dubbed "Cure MN " (Cure MotorNeuron ) aims to leverage human motor neuron assays based on ALS patient-derived induced ...
    9-12-2013
  • Top 20 Grant-Giving Disease Foundations
    ... Awarded: $116.872 million % Awarded as Grants: 90.9% Headquarters: Dallas, TX #9. The ALS Association % of Revenues Awarded as Grants: 18.4% Year Ended January 31, 2012, Total ...
    5-21-2013
  • Denovo Partners with ALS Nonprofit to ID Biomarkers
    The ALS Emergency Treatment Fund (ALS-ETF) and Denovo Biomarkers are partnering in a pharmacogenomics-based effort to identify potential responder groups for drugs being studied in ...
    5-10-2013
  • Stem Cell Screen Reveals Promising Target for ALS
    killed in amyotrophic lateral sclerosis (ALS; Lou Gehrig's disease) than two drugs that ... discovery to ALS. The disease is associated with the progressive death of motor neurons. ...
    4-19-2013
  • BMS, Vertex Plan Phase II Studies of Hep C Combo Therapy
    ... Vertex gained worldwide rights to VX-135, which until Phase II studies was named ALS-2200, through an exclusive licensing agreement signed with Alios BioPharma, in June 2011. The ...
    4-5-2013
  • Medicine: Getting Personal
    ... of fetal-derived neural stems cells in patients with amyotrophic lateral sclerosis (ALS), for example. 6. Smith and Nephew announces acquisition of bioactive woundcare company ...
    3-15-2013
  • Can Fat Fight Brain Cancer?
    ... MSCs, whether derived from bone marrow or fat, have been studied in animal models to treat trauma, Parkinson's disease, ALS, and other diseases. Results of this Johns Hopkins ...
    3-12-2013
  • Addressing Unmet Medical Needs with Complex Carbohydrate Chemistry
    ... It is involved in many pathological conditions such as heart attack, brain injuries and stroke, neurodegenerative diseases such as Alzheimer's dementia, Lou Gehrig's disease (ALS), ...
    2-28-2013
  • Biogen Idec ALS Drug Strikes Out
    sclerosis (ALS or Lou Gehrig's disease), after the drug candidate failed a pivotal Phase III clinical trial-though the company insisted that it remains committed to ALS research. ...
    1-4-2013
  • The New Economics of Orphan Diseases
    ... 2002 and 2010. For myasthenia gravis, the growth rate is expected to be 6.3% between 2010 and 2017, up from 3.9% between 2002 and 2010. ALS therapeutics, however, will slow. ...
    1-1-2013
  • ALS Research Consortium Spearheaded by Biogen Idec
    (ALS). Participants hope that coordinating research and sharing results across various disciplines will greatly accelerate the understanding of the mechanism of ALS and the ...
    12-20-2012
  • ALS TDI Adds Another Partner
    The ALS Therapy Development Institute (ALS TDI) and the Gladstone Institutes formed a research collaboration to speed the discovery of potential treatments for ALS. About 30,000 ...
    12-4-2012
  • In Vitro Clinical Trials: Not that Far-Fetched
    ... Stroke (NINDS) funded three consortia to develop iPS cell lines from individuals with Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and Huntington's disease (HD). ...
    10-31-2012
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    Journal Articles

  • Cysteine, Sulfite, and Glutamate Toxicity: A Cause of ALS?
    Patricia B.E. Woolsey
    Journal of Alternative and Complementary Medicine, The
    Cysteine, Sulfite, and Glutamate Toxicity: A Cause of ALS? Journal of Alternative and Complementary Medicine, The Abstract Background: Amyotrophic lateral sclerosis (ALS) of ...
  • Aggregation of Copper-Zinc Superoxide Dismutase in Familial and...
    Madhuri Chattopadhyay, Joan Selverstone Valentine
    Antioxidants & Redox Signaling
    Aggregation of Copper-Zinc Superoxide Dismutase in Familial and Sporadic ALS Antioxidants & Redox Signaling Abstract Amyotrophic lateral sclerosis (ALS) is a progressive, fatal ...
  • Gene Therapy for Amyotrophic Lateral Sclerosis (ALS) Using a...
    N. A.-M. Pochon, B. Heyd, N. Déglon, J.-M. Joseph, A. D. Zurn, E. E. Baetge, J. P. Hammang, M. Goddard, M. Lysaght, F. Kaplan, A. C. Kato, M. Schluep, L. Hirt, F. Regli, F. Porchet, N. De Tribolet, P. Aebischer
    Human Gene Therapy and Part B: Methods
    Gene Therapy for Amyotrophic Lateral Sclerosis (ALS) Using a Polymer Encapsulated ... neurotrophic factor (hCNTF) for the treatment of Amyotrophic Lateral Sclerosis (ALS). ...
  • Axonal Mitochondrial Clusters Containing Mutant SOD1 in Transgenic...
    Jose R. Sotelo-Silveira, Paola Lepanto, Victoria Elizondo, Sofia Horjales, Florencia Palacios, Laura Martinez-Palma, Monica Marin, Joseph S. Beckman, Luis Barbeito
    Antioxidants & Redox Signaling
    Axonal Mitochondrial Clusters Containing Mutant SOD1 in Transgenic Models of ALS ... mounts of microdissected motor axons of rats expressing the ALS-linked SOD1-G93A mutation. ...

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