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  • BARDA Exercises $6M Option for Aeolus' Acute Radiation Syndrome...
    The Biomedical Advanced Research and Development Authority (BARDA) exercised $6 million in additional contract options under its advanced research and development contract with ...
    9-18-2013
  • Closer-to-Real 3D Cell Culture Advances
    New in vitro technologies have a real chance of replacing animal models for drug testing, yet some challenges remain. As the 360 government-owned chimpanzees officially retired on ...
    7-3-2013
  • NeuroVive, Isomerase Team Up to Study Cyclophilin Inhibitor
    NeuroVive Pharmaceutical has signed a collaboration agreement with Isomerase Therapeutics to develop cyclophilin-inhibiting molecules from a portfolio it acquired in March from ...
    6-13-2013
  • Harnessing the Power of Kinase Inhibitors
    The assay development and high-throughput screening system at the European ScreeningPort, Hamburg, Germany. The ~600 kinases that make up the human kinome comprise a group of ...
    5-8-2013
  • New International Collaboration Aims to Develop Drugs, Diagnostics...
    drug discovery, medicinal chemistry, biochemical and cellular assay development, ADME/tox, DMPK, and multiple in vivo efficacy/toxicology models, among other things. ...
    5-2-2013
  • Predicting Drug Toxicity in Humans
    At the "International Conference on Predictive Human Toxicity and ADME/Tox Studies", experts from the biotech and pharma industry discussed recent advances toward accurately ...
    4-1-2013
  • Failures Prompt Tranzyme to Evaluate Its Future
    Buffeted by the failure of two of its drug candidates in clinical trials, Tranzyme Pharma said today its Board of Directors agreed to explore and evaluate strategic ...
    2-8-2013
  • Bringing Toxicity Prediction to Chemists' Desktops
    Optibrium and Lhasa entered into a technology collaboration agreement that will integrate Lhasa's Derek Nexus(tm) platform for knowledge-based prediction of compound toxicity as an ...
    2-4-2013
  • Galapagos Deals Aim to Shore Up Drug Discovery
    A month after submitting an Investigational New Drug application for its lead candidate to the FDA, Belgian-owned small molecule and antibody discoverer Galapagos moved to ...
    1-15-2013
  • Better, Earlier ADME/Tox Predictions in Cells
    Whole-animal models are still the gold standard for toxicity predictions and are required by regulatory agencies, yet for many biological pathways and mechanisms they do not ...
    12-1-2012
  • Compound Family Found for Parkinson's Disease Therapy
    Scientist have developed a small molecule drug candidate that selectively inhibits a rare class of calcium channel that's implicated in the pathogenesis of Parkinson's disease. ...
    10-25-2012
  • Sigma Divisions Establish Screening Technology Deals
    Sigma Life Sciences separately announced a deal with ADME/tox services firm Cyprotex, through which the latter will be able to offer its clients knockout transporter screening ...
    10-16-2012
  • Fine-Tuning Cell-Based Assays
    ... Improved, long-lasting hepatocyte cultures could revolutionize toxicity testing. Okey Ukairo, Ph.D., senior principal scientist, ADME/Tox services, at Hepregen, discussed his ...
    9-15-2012
  • Acquisitions Grow Corning's Product Line
    Firm Has Been Snapping Up Companies to Expand and Enhance Its Life Science Offerings The recent acquisitions and collaborations made by Corning Life Sciences, combined with new ...
    9-15-2012
  • New Liver Toxicity Services Based on 3D Microtissues
    CRO Cyprotex offers preclinical in vitro and in silico ADME/Tox services to drug discovery, pharma, and academic/nonprofit organizations worldwide. InSphero is a specialist in 3D ...
    9-14-2012

  • Journal Articles

  • Quantitative Structure-Activity Relationship Analysis of 4(3H...
    Vikas Srivastava, Deepa Sinha, Anjani K. Tiwari, Himanshu Sharma, Raj Bala Sharma, Vinay K. Singh, Anil K. Mishra
    Cancer Biotherapy and Radiopharmaceuticals
    Quantitative Structure-Activity Relationship Analysis of 4(3H)-Quinazolone Derivatives as Tyrosine Kinase Inhibitors by Multiple Linear Regression Cancer Biotherapy and ...
  • Drug Discovery in the Kinase Inhibitory Field Using the Nested...
    György Kéri, Zsolt Székelyhidi, Péter Bánhegyi, Zoltán Varga, Bálint Hegymegi-Barakonyi, Csaba Szántai-Kis, Doris Hafenbradl, Bert Klebl, Gerhard Muller, Axel Ullrich, Dániel Erös, Zoltán Horváth, Zoltán Greff, Jenö Marosfalvi, János Pató, István Szabadkai, Ildikó Szilágyi, Zsolt Szegedi, István Varga, Frigyes Wáczek, László Örfi
    ASSAY and Drug Development Technologies
    All the compounds in our NCL library are stored in a big unified Structured Query Language database along with their measured and calculated physicochemical and ADME/toxicity ...

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