Cryptogram Challenge: RNAi-2

Year Created: 2010

Cryptogram Challenge: RNAi-2, a follow-on cryptogram to the recently solved Cryptogram Challenge: RNAi depicts an array of pairs of cells expressing a red protein before and after transfection with an siRNA directed against the gene that expresses the protein. Transfection with siRNA is rapidly becoming an essential tool for molecular and cell biologists. Cryptogram Challenge: RNAi-2 takes advantage of the power of siRNA to control gene expression to both illustrate the variability of cellular responses and to provide a cryptogram that should tease your imagination. The RNAi-2 challenge while similar in appearance to the first RNAi challenge will require additional skills to solve.

Cryptogram Challenge: RNAi-2 when solved will reveal a brief message that illuminates the power of the scientist to control cellular behavior.

Peter C. Johnson, M.D.

Peter C. Johnson, M.D., is the President and CEO of Scintellix, LLC, a company that applies quantitative decision analytics tools to the process of team development. He is the creator of the popular GEN contest "Microarray Challenge" based on the MicroArray (2008) image and is the author of multiple graphic arts books, scientific books, and manuscripts in the fields of thrombosis and tissue engineering. He is also the creator of GEN's last three contests, the "Cryptogram Challenge" based on the "96 Well" (2009) ELISA plate image, the "Cryptogram Challenge: ELISA Redux" based on a related image, and the "Cryptogram Challenge: RNAi," a transfection-focused cryptogram. He formerly practiced reconstructive surgery, founded the Pittsburgh Tissue Engineering Initiative, and co-founded and was CEO of TissueInformatics, Inc. Dr. Johnson is presently the co-editor in chief of the journal Tissue Engineering (Parts A, B, and C). Dr. Johnson serves on multiple boards and is the National Chair of the University of North Carolina Medical Excellence Fund.

About Scintellix, LLC

Scintellix, LLC, located in Raleigh, NC, applies Decide—S³ Analytics™—Making Decisions Digital™ to solve complex business problems. Decide—S³ Analytics uniquely weaves teams together through the co-generation of quantitative solutions. It can be effectively applied in all forms of strategic planning, board-composition analysis, opportunity stratification, as well as to many other challenging areas. www.scintellix.com

Copyright 2010, Peter C. Johnson, M.D.

Decode the cipher hidden in this 96-well plate.

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