Aug 21 2009, 9:00 AM EST
GEN News Highlights
Sigma-Aldrich reports that it will create genetically engineered rodent research models using its CompoZr™ zinc finger nuclease (ZFN) gene-editing technology. Initial selections of genetically engineered animal models and a service platform for development of custom rodent models are scheduled to be available late 2009, according to the company.
Development will be carried out at the Sigma Advanced Genetic Engineering (SAGE) Labs in St. Louis. The scientists will initially create knockout rat models with a focus on toxicology, neuroscience, as well as cardiovascular and inflammatory diseases.
Sigma-Aldrich says that mice can be generated in four months, or in about one-third the time it takes to make a knockout model using conventional ES-cell-based approaches. “The knockout rat is a long-awaited milestone in the scientific community and we are pleased that Sigma innovation has played such a key role in its development,” says Dave Smoller, Ph.D., president, Sigma Research Biotechnology.
Sigma-Aldrich joined forces with Sangamo Biosciences in June 2007 to commercialize ZFN technology for research purposes. In January 2009, Sangamo reported having achieved a key production capacity milestone a year ahead of schedule, triggering a $1.0 million fee from Sigma-Aldrich.
The use of ZFN technology to create rats with targeted gene deletion was published in the July 24 issue of Science. The rats, according to the paper titled “Knockout Rats via Embryo Microinjection of Zinc-Finger Nucleases,” had permanent heritable gene mutations.
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Related News
Scientists Create Targeted Knockout Rats Using Sangamo’s Zinc Finger Nuclease Technology (July 24, 2009)
Roche Gains Access to Sangamo’s Gene Regulation Platform (July 9, 2008)
Sangamo BioSciences Signs License Agreement with Open Monoclonal Technologies for Use of ZFP Technology (Apr. 7, 2008)
Sigma-Aldrich and Sangamo Ink Deal to Develop Zinc Finger-Based Lab Research Reagents (July 11, 2007)
Genentech Deploys Sangamo Platform for Protein Pharmaceutical Production (Apr. 30, 2007)
8/21/2009
For access to the public database of random knockout rat models, please visit the Knock Out Rat Consortium website at www.knockoutrat.org and click the orange Rat Models button.
Over 100 Knockout Rats and ENU rat mutants, including the world’s first knockout rat model of severe combined immunodeficiency, or SCID, are available commercially through Transposagen – www.transposagenbio.com
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