May 7 2007, 11:45 AM EST
PRNEWSWIRE
The AlloMap test, currently used to detect the absence of heart transplant rejection, in the place of unneeded invasive protocol heart muscle biopsies, has now been shown to correlate with oxygen saturation levels, cardiac filling pressures, and the electrical properties of the transplanted heart.
Additionally, data from the Lung Allograft Rejection Gene expression Observation (LARGO) study presented at the ATC sessions demonstrate that peripheral blood gene expression profiling can detect cytomegalovirus-induced immune responses in lung transplant patients.
"These data continue to validate the outcomes of the Cardiac Allograft
Gene Expression Observational (CARGO) study and the potential value of
developments from the LARGO study, Mario C. Deng, M.D., director of Cardiac
Transplantation Research,
In separate studies, recently released at the 2007 ISHLT meeting, the non- invasive AlloMap molecular expression test demonstrated that it could be used to safely reduce the use of immunosuppressants while decreasing the frequency of invasive biopsy and preventing organ rejection.
More information on ATC can be found at www.atcmeeting.org.
About XDx
XDx's mission is to improve patient care by developing molecular diagnostics that translate an individual's immune status into clinically actionable information. Founded in 2000, XDx is a molecular diagnostics company that utilizes state-of-the-art genomic technology and sophisticated bioinformatics analyses to understand and measure the immune processes that underlie specific immune-mediated conditions. Physicians can use this information to optimize patient treatment and minimize the long-term consequences of immunosuppressive therapies.
XDx's science and technology is now being evaluated in patients with solid organ transplants. Building on the discoveries made during the development of AlloMap testing for heart transplant patients, which included the identification of many genes and pathways involved in tissue rejection, XDx is now developing a product for use by physicians to better manage lung transplant patients. Beyond the use of AlloMap testing in assessing immune response in solid organ transplantation, XDx scientists are applying similar approaches to create new molecular diagnostic tests for the improved clinical management of immune-mediated inflammatory diseases, such as systemic lupus erythematosus (SLE or lupus,) to diagnose and predict clinical flares common in a variety of these diseases.
In addition to its potential for use by physicians for better patient management, the XDx approach is of interest to pharmaceutical companies looking to use biomarkers predictive of drug efficacy in order to proactively identify patient response and to better target their drug development efforts and clinical trials.
More information can be found at www.xdx.com.
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