TripleTOF 4600 system is designed for a variety of applications, including high-throughput discovery proteomics and routine and comprehensive analysis of drug metabolites in early ADME. The system is designed as a workhorse instrument, combining rapid acquisition rates with strategies that can increase the benefits of UHPLC separations for high-resolution-mass MS and MS/MS data. The TripleTOF 4600 system is designed for a variety of applications, including high-throughput discovery proteomics and routine and comprehensive analysis of drug metabolites in early ADME. The system is designed as a workhorse instrument, combining rapid acquisition rates with strategies that can increase the benefits of UHPLC separations for high-resolution-mass MS and MS/MS data.