The Hyb-Ice thermal profiling system is an alternative to a standard thermal cycler for performing everyday temperature profiles. The system consists of a programmable heating/cooling base and removable block that heat and cool samples from 4 to 99°C. The system accommodates a variety of quick-change blocks to fit most tubes or plates. The Hyb-Ice system also provides temperature regulation, uniformity, and ramp rates and performs PCR in either standard or large volume tubes. A noncontact heated lid controls condensation. Programs can be stored or run via an onboard USB drive.