The surface of the Sartopore® Platinum polyethersulfone filter membrane has been modified using a hydrophilic and thermostable polymer. This surface modification gives the membrane good wetting properties and reduces its protein binding. Fewer than five liters of WFI (water for injection) are needed to wet a 10” Sartopore Platinum cartridge for subsequent integrity testing. Sartopore Platinum filter cartridges can be dry-steam sterilized in the forward or the reverse direction, without altering the properties of their membrane. These sterilizing-grade filters can be used in the pH range from 1 to 14 and thus for most filtration applications in biopharmaceutical manufacturing.