GS GType TET2/CBL/KRAS and the GS GType RUNX1 primer sets are designed for comprehensive genetic variation detection in four key human genes using the 454 GS Junior and GS FLX Systems. The sequence-based assays offer a solution for cancer researchers investigating the human TET2, CBL, KRAS, and RUNX1 genes. The assays enable deep sequencing of PCR amplicons covering key exon regions, and offer ample sensitivity and time to result. The assays include primer plates, protocols, and dedicated analysis software.