Designed for high-throughput, small-scale protein purification, the Janus® BioTx Pro automated workstation accommodates multiple chromatography modes (column, tip, and batch). The Janus BioTx Pro also enables small-scale purification of µg to mg proteins on one system instead of three individual dedicated systems, supporting the use of commercially available plate- and column-based screening tools. Applications for the workstation include resin-binding studies and conditions screening.