The Amicon Pro® solution can combine protein purification steps into one device, streamlining workflow and reducing protein loss. Combining the bind, wash, elute, and concentration steps into one device, the Amicon Pro purification system can help avoid sample transfers and reduce hands-on time. The device integrates affinity-based spin column purification with downstream sample concentration and buffer exchange. Featuring a reservoir that accommodates a range of sample volumes, the device reduces the need for multiple washing and elution steps.