Phree phospholipid removal plates can allow for fast cleanup of plasma samples in pharmaceutical and clinical research laboratories. In one step, Phree can remove both proteins and phospholipids and deliver the prepared plasma to a collection plate. The high-capacity Phree sorbent can process up to 400 µL per well and remove 99 to 100% of lysophosphatidyl and phosphatidyl cholines, which are not removed when a simple protein precipitation is performed. The plate format enables the simultaneous processing of 96 samples.