The PDMS Chip Interface allows users to create reliable and leak-free fluidic connections to PDMS chips. The interface allows chips to be used outside the lab, which can widen applications for PDMS chips beyond research as well as the opportunity for greater collaboration between research labs. The microfluidic device can not only reduce the downtime for microfluidic experiments due to leakage issues but also allow rapid changeover between different chip designs. To be used with the PDMS Chip Slide and Linear Connector 4-way, the PDMS Chip Interface accommodates a range of PDMS device heights, making it possible for users to design their own PDMS chips.