A nonmetallic, cone-bottomed media slurry tank is available for process-scale chromatography and other biotech applications. It is made of plastic—translucent polyethylene or polypropylene—to reduce the oxidization and pitting often seen with stainless tanks and the associated risk of cross-contamination. It comes in sizes ranging from 200 to 2,000 L, and it features a vertically aligned shaft equipped with both a main turbine, which circulates the fluid in the tank, and a tickler impeller that reaches into the tank’s cone bottom to stir up anything that may have settled. A rotating spray-ball system permits cleaning in place, while a removable lid permits cleaning out of place.