The NEPHELOstar Plus is a laser-based nephelometer that measures light-scattering in a microplate-based environment. Light-scattering is an alternative to absorbance measurements and it is a technique that measures the turbidity or solubility of a sample in a solution. The NEPHELOstar Plus detects insoluble particles in liquid samples by measuring forward scattered light. Possible applications include: compound solubility screening, microbial cell growth kinetics, antibody-antigen interaction, immunoprecipitation, and polymerization monitoring.