Expressionist MSX® analyzes proteomics and metabolomics data for a variety of applications directly from the instrument. It can be downloaded in a Windows-executable file and can be set up in minutes. The algorithms in Expressionist MSX can reduce the number of false-positive and false-negative biomarkers. Expressionist MSX is packaged with support for a range of proteomic and metabolomic MS setups such as LC-MS/MS, SILAC, MRM, and GC-MS. The system can be applied in studies including biomarker discovery and validation, protein profiling, peptide identification and quantification, protein-protein interaction, and metabolic profiling within drug development.