The Q Exactive™ high-performance benchtop quadrupole-Orbitrap LC-MS/MS brings together quadrupole precursor selection and high-resolution accurate mass (HR/AM) Orbitrap mass analysis to deliver quantitative and qualitative workflows. With HR/AM Quanfirmation™ capability, the Q Exactive mass spectrometer makes it possible to identify, quantify, and confirm more trace-level metabolites, contaminants, peptides, and proteins in complex mixtures in one analytical run. High confidence results are obtained without sacrificing MS/MS sensitivity, mass resolution, or quantitative reproducibility.