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Sep 1, 2014 (Vol. 34, No. 15)

Promega

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Mass Spec Reagents

The IdeS Protease enables fast, easy, and high-performance digestion of immunoglobulin, while the Human and Yeast Protein Extracts provide a test material for optimizing mass spec sample preparation. IdeS Protease is a recombinant, engineered version of the immunoglobulin-degrading enzyme from Streptococcus pyogenes. It is a highly specific protease that slices Immunoglobulin G (IgG) at a single, targeted site, offering 100% digestion in 30 minutes with no optimization. IdeS can be used to characterize therapeutic antibody candidates using LC/MS, and contains a histidine tag for easy removal. The versatile Promega IdeS enzyme cuts IgGs from a range of species, as well as Fc-fusion proteins. 

  • Promega
  • 2800 Woods Hollow Road
  • Madison, WI, 53711
  • UNITED STATES

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