The ultrafleXtreme™ MALDI TOF/TOF system features Top-Down T3-Sequencing for revealing terminal modifications, post-translational modifications, and sequence impurities. High-resolution intact biomolecule analysis is possible on the ultrafleXtreme platform. It incorporates the smartbeam™ laser, with up to 2 kHz repetition rate with true-pixel image resolution at 20 µm for proteins. The MALDI-TOF/TOF system can generate multiply charged intact protein ions for measurements with mass resolution of greater than 30,000, which can yield isotopic information for 30 kDa proteins, and larger protein molecular weight assignments with better than 15 ppm mass accuracy.