The 1290 Infinity Multisampler, a liquid chromatography autosampler, provides newly optimized, scalable throughput capacity. Using shallow well-plate drawers, the 1290 Infinity Multisampler takes a maximum load of 16 microtiter plates and up to 6,144 samples. Features include a dual-needle injector set-up that enables optimal injection speed as well as flexibility for injections. New software features improve workflow efficiency and enable easy data-entry of large sample sets. Internal robotics move microtiter plates and other sample containers from the sample hotel to the central workspace for sample processing steps and injections. With multiwash capability, it can reduce carryover to less than 10 parts per million.