The Orbitrap Fusion LC-MS combines its three mass analyzers—quadrupole, Orbitrap, and linear ion trap—in a “Tribrid” architecture that offers depth of analysis of complex biological samples. This Tribrid configuration allows users to identify large numbers of low-abundance proteins. Its architecture enables simultaneous precursor isolation, fragmentation, and data acquisition in both the Orbitrap and linear ion trap mass analyzers. The Orbitrap Fusion system also features a drag-and-drop method editor that can remove guesswork from setting up complex methods.