The Exactive Plus system is a benchtop liquid chromatography-mass spectrometry (LC-MS) system for high-throughput screening, identification, and quantification of compounds in complex matrices. Powered by Orbitrap technology, the Exactive Plus system features advanced signal processing, ion optics, and transmission technologies. It produces full-scan HR/AM data, minimizing MS method development and allowing retrospective data analysis. The system has a range of applications, including environmental, drug metabolism/pharmacokinetics research, and intact antibody analyses.