Designed for trace quantitative work in complex matrices, the LCMS-8080 achieves a low femtogram-to-attogram range detection limit for various compounds with ion source and interface technologies, which can reduce chemical background. The LCMS-8080 delivers good performance with UHPLC and stability and reliability in data acquisition, including when the ionization polarity is rapidly switched. It can provide ruggedness when measuring target compounds in complex matrices, deliver quality data for an extended period, and can also reduce the instrument down time.