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June 1, 2013 (Vol. 33 , No. 11)

iPS Cell Lines

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Cellectis bioresearch

The iPS Engineering Hub™ service can provide users with customized iPS cell lines engineered with TALEN™ technology. Donated somatic cells are reprogrammed by means of co-expressing four factors (Oct-4, SOX2, c-Myc, and Klf-4) by nonintegrating techniques. The iPS cell engineering part is based on standard TALEN projects—gene knockout, gene modification (such as gene tagging, promoter swap, or nucleotide substitution)—adapted with respect to stem cell biology requirements.

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