The UVP Hanging Drop Crystallization Plate Seal comes with a dust-free protective coating and a specialty polymer base. The product’s 100-micron-thin layer of UVP specialty polymer can enable compact drop creation while avoiding any noticeable diffraction of X-rays. In addition, the seal can be used in the ultraviolet range, enabling salt recognition under an ultraviolet source microscope. The seal can accommodate up to three separate drops of protein and fit the standard two- and three-drop MRC plates. Sealing depends on an adhesive that is validated not to ingress into sample or lead to seal corruption. Crystals can be removed by peeling back the seal or cutting with a scalpel.