The Irys™ is a genome mapping system that can help genomics researchers with structural variation analysis and sequence assemblies. Irys is an automated platform that uses single-molecule imaging to visualize extremely long nucleic acids and reveal genome architecture in its native state. The fully automated Irys benchtop instrument uses an IrysChip to uncoil and confine long DNA molecules into nanochannels, uniformly linearizing them for high-resolution imaging. The Irys system does not require DNA fragmentation and amplification, resulting in long reads of hundreds of kilobases to megabases.